CAJ | 학술논문

目的评价芬太尼透皮贴联合普瑞巴林治疗带状疱疹后神经痛的临床效果. 方法 56 例PHN患者随机分为实验组( A 组)和对照组( B 组). A 组:普瑞巴林150 mg,2 次/d 口服,联合应用芬太尼透皮贴4. 2 mg,每72 h更换1次;B组:单独应用口服普瑞巴林150 mg,2次/d口服. 两组分别治疗8 周. 记录两组患者用药前及用药后2、4、6、8周时的疼痛评分( VAS评分)、生活质量评分( SF-36评分)及不良反应. 结果治疗前,A、B组的VAS评分为7. 79±0. 92、7. 70±0. 87,治疗2周后降至3. 89±1. 07、6. 33±0. 73 (P<0. 05),组间比较差异也有统计学意义(P<0. 05),治疗后4、6、8周亦存在相似情况. 治疗后8周,两组SF-36评分与治疗前比较,除一般健康状况和心理健康外,其余各项差异均有统计学意义;A组恶心呕吐和便秘发生率高于B组. 结论芬太尼透皮贴联合普瑞巴林对PHN患者的临床效果优于单独应用普瑞巴林,不良反应较小.
목적 평개분태니투피첩연합보서파림치료대상포진후신경통적림상효과. 방법 56 례PHN환자수궤분위실험조( A 조)화대조조( B 조). A 조:보서파림150 mg,2 차/d 구복,연합응용분태니투피첩4. 2 mg,매72 h경환1차;B조:단독응용구복보서파림150 mg,2차/d구복. 량조분별치료8 주. 기록량조환자용약전급용약후2、4、6、8주시적동통평분( VAS평분)、생활질량평분( SF-36평분)급불량반응. 결과 치료전,A、B조적VAS평분위7. 79±0. 92、7. 70±0. 87,치료2주후강지3. 89±1. 07、6. 33±0. 73 (P<0. 05),조간비교차이야유통계학의의(P<0. 05),치료후4、6、8주역존재상사정황. 치료후8주,량조SF-36평분여치료전비교,제일반건강상황화심리건강외,기여각항차이균유통계학의의;A조악심구토화편비발생솔고우B조. 결론 분태니투피첩연합보서파림대PHN환자적림상효과우우단독응용보서파림,불량반응교소.
Objective To observe the effect of fentanyl transdermal patches combined with pregabalin on PHN. Methods Fifty-six patients were divided into experimental group ( group A) and control group ( group B) ran-domly. Group A was treated with fentanyl transdermal patches 4. 2 mg per 72 h. Group A and group B were orally ad-ministered pregabalin 150 mg/d. The course of treatment were 8 weeks. The analgesic effect (VAS score),quality of life (SF-36 score) and adverse reactions were recorded before treatment and at 2,4,6,8 weeks after treatment. Results After 2 weeks' treatment,the VAS scores of both group decreased (P<0. 05),there was significant difference be-tween the two groups (P<0. 05),and so as the situation at 4,6 and 8 weeks after treatment. Except the general health and mental health,there was significant difference in SF-36 score between the two groups (P<0. 05). The incidences of nausea and vomiting and constipation were higher in group A than those in group B (P<0. 05). Conclusion The combination of fentanyl transdermal patches and pregabalin is effective and safe for the patients with PHN.