实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
10期
1211-1213
,共3页
右美托咪定%高血压%血流动力学%全身麻醉
右美託咪定%高血壓%血流動力學%全身痳醉
우미탁미정%고혈압%혈류동역학%전신마취
Dexmedetomidine%Hypertension%Hemodynamics%General anesthesia
目的 探讨分析低剂量右美托咪定对全身麻醉高血压手术患者的血流动力学及术后麻醉效果的影响. 方法 选择2014年2月至2015年1月择期在全麻下行腹部手术的患者60例,随机分为观察组和对照组,每组30例,均采用静吸复合全身麻醉. 观察组给予静脉泵入右美托咪定0. 3 μg/( kg·h),对照组给予相等量的0. 9%生理盐水泵入. 分别观察注药前( T0 )、气管插管前1 min ( T1 )、气管插管时( T2 )、气管插管后 1 min ( T3 )、拔管前1 min ( T4 )、拔管后1 min ( T5 )时的血压、心率( HR)、术后镇静评分Ramsay及不良反应. 结果 两组患者手术时间、术中出血量等一般情况,以及拔管时间、麻醉时间、苏醒时间和不良反应发生率比较差异无统计学意义(P>0. 05). 观察组患者T1 ~T5 时的血压及心率比T0 时明显下降,差异有统计学意义(P<0. 05);对照组患者T1 时的血压、心率较T0 时明显下降,但T2 ~T5 时血压及心率较T0 时升高(P<0. 05). 两组患者T0、T1 时血压、心率比较差异无统计学意义(P>0. 05),但观察组T2 ~T5 时血压、心率低于对照组(P<0. 05),T1 ~T5 时RSS评分高于对照组(P<0. 05). 结论 低剂量右美托咪定对全身麻醉的高血压患者可产生明显的镇静、镇痛效应,有助于保持血流动力学稳定.
目的 探討分析低劑量右美託咪定對全身痳醉高血壓手術患者的血流動力學及術後痳醉效果的影響. 方法 選擇2014年2月至2015年1月擇期在全痳下行腹部手術的患者60例,隨機分為觀察組和對照組,每組30例,均採用靜吸複閤全身痳醉. 觀察組給予靜脈泵入右美託咪定0. 3 μg/( kg·h),對照組給予相等量的0. 9%生理鹽水泵入. 分彆觀察註藥前( T0 )、氣管插管前1 min ( T1 )、氣管插管時( T2 )、氣管插管後 1 min ( T3 )、拔管前1 min ( T4 )、拔管後1 min ( T5 )時的血壓、心率( HR)、術後鎮靜評分Ramsay及不良反應. 結果 兩組患者手術時間、術中齣血量等一般情況,以及拔管時間、痳醉時間、囌醒時間和不良反應髮生率比較差異無統計學意義(P>0. 05). 觀察組患者T1 ~T5 時的血壓及心率比T0 時明顯下降,差異有統計學意義(P<0. 05);對照組患者T1 時的血壓、心率較T0 時明顯下降,但T2 ~T5 時血壓及心率較T0 時升高(P<0. 05). 兩組患者T0、T1 時血壓、心率比較差異無統計學意義(P>0. 05),但觀察組T2 ~T5 時血壓、心率低于對照組(P<0. 05),T1 ~T5 時RSS評分高于對照組(P<0. 05). 結論 低劑量右美託咪定對全身痳醉的高血壓患者可產生明顯的鎮靜、鎮痛效應,有助于保持血流動力學穩定.
목적 탐토분석저제량우미탁미정대전신마취고혈압수술환자적혈류동역학급술후마취효과적영향. 방법 선택2014년2월지2015년1월택기재전마하행복부수술적환자60례,수궤분위관찰조화대조조,매조30례,균채용정흡복합전신마취. 관찰조급여정맥빙입우미탁미정0. 3 μg/( kg·h),대조조급여상등량적0. 9%생리염수빙입. 분별관찰주약전( T0 )、기관삽관전1 min ( T1 )、기관삽관시( T2 )、기관삽관후 1 min ( T3 )、발관전1 min ( T4 )、발관후1 min ( T5 )시적혈압、심솔( HR)、술후진정평분Ramsay급불량반응. 결과 량조환자수술시간、술중출혈량등일반정황,이급발관시간、마취시간、소성시간화불량반응발생솔비교차이무통계학의의(P>0. 05). 관찰조환자T1 ~T5 시적혈압급심솔비T0 시명현하강,차이유통계학의의(P<0. 05);대조조환자T1 시적혈압、심솔교T0 시명현하강,단T2 ~T5 시혈압급심솔교T0 시승고(P<0. 05). 량조환자T0、T1 시혈압、심솔비교차이무통계학의의(P>0. 05),단관찰조T2 ~T5 시혈압、심솔저우대조조(P<0. 05),T1 ~T5 시RSS평분고우대조조(P<0. 05). 결론 저제량우미탁미정대전신마취적고혈압환자가산생명현적진정、진통효응,유조우보지혈류동역학은정.
Objective To investigate the hemodynamic effect and anesthesia efficacy of low-dose dexmedeto-midine infusion on patients with hypertension under general anesthesia. Methods Sixty patients scheduled for abdomen operation under inhalational combined with intravenous anesthesia from February 2014 to January 2015 were randomly divided into two groups. Group A (n=30) received 0. 3 μg/(kg·h) of dexmedetomidine intravenously,group B (n=30) received the same volume of 0. 9% saline. The blood pressure,heart rate (HR),and postoperative Ramsay sedation scores and adverse reactions were recorded before injection ( T0 ),at 1 min before intubation ( T1 ),at the time point of intubation (T2),at 1 min after intubation (T3),at 1 min before extubation (T4),at 1 min after extubation (T5). Re-sults There was no significant difference in the operation time,blood loss,extubation time,anesthesia time,recovery time and the incidence of adverse reactions between the two groups (P>0. 05);In group A,the blood pressure and heart rate was significantly diminished at T1 ~T5 compared with those at T0(P<0. 05);In Group B,the blood pressure and heart rate was significantly diminished at T1 and increased at T2 ~T5 compared with T0(P<0. 05). The blood pres-sure and heart rate in group A was lower than that of group B at T2 ~T5,and the RSS score was higher at T1 ~T5 ( P<0. 05). Conclusion Low-dose dexmedetomidine infusion on patients with hypertensive during general anesthesia can provide more satisfactory sedative and analgesia effects.
