实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
10期
1252-1255
,共4页
瑞司瓜特%可溶性鸟苷酸环化酶%肺动脉高压%慢性血栓栓塞性肺动脉高压
瑞司瓜特%可溶性鳥苷痠環化酶%肺動脈高壓%慢性血栓栓塞性肺動脈高壓
서사과특%가용성조감산배화매%폐동맥고압%만성혈전전새성폐동맥고압
Riociguat%Soluble guanylate cyclase%Pulmonary arterial hypertension%Chronic thromboembolic pul-monary hypertension
瑞司瓜特为首创可溶性鸟苷酸环化酶( sGC)激动剂,获批用于治疗肺动脉高压( PAH)和慢性血栓栓塞性肺动脉高压( CTEPH). 本文综述了口服瑞司瓜特的作用机理及其对成人PAH 或CTEPH的临床效果与耐受性. 结果表明,瑞司瓜特对PAH和不能手术或做过肺动脉内膜切除术后顽固、复发的CTEPH患者有效,且耐受性良好,可以改善患者运动能力、肺血液动力学参数、WHO功能分级.
瑞司瓜特為首創可溶性鳥苷痠環化酶( sGC)激動劑,穫批用于治療肺動脈高壓( PAH)和慢性血栓栓塞性肺動脈高壓( CTEPH). 本文綜述瞭口服瑞司瓜特的作用機理及其對成人PAH 或CTEPH的臨床效果與耐受性. 結果錶明,瑞司瓜特對PAH和不能手術或做過肺動脈內膜切除術後頑固、複髮的CTEPH患者有效,且耐受性良好,可以改善患者運動能力、肺血液動力學參數、WHO功能分級.
서사과특위수창가용성조감산배화매( sGC)격동제,획비용우치료폐동맥고압( PAH)화만성혈전전새성폐동맥고압( CTEPH). 본문종술료구복서사과특적작용궤리급기대성인PAH 혹CTEPH적림상효과여내수성. 결과표명,서사과특대PAH화불능수술혹주과폐동맥내막절제술후완고、복발적CTEPH환자유효,차내수성량호,가이개선환자운동능력、폐혈액동역학삼수、WHO공능분급.
Riociguat is a soluble guanylate cyclase stimulator,it is a first-in-class drug approved for the treat-ment of patients with pulmonary arterial hypertension ( PAH ) or chronic thromboembolic pulmonary hypertension (CTEPH). This article reviews the pharmacological properties of oral riociguat and the clinical efficacy and tolerability in adults with PAH or CTEPH. It is indicated that riociguat is effective and well tolerated in patients with PAH and in patients with inoperable CTEPH or persistent/recurrent CTEPH following pulmonary endarterectomy,it has a positive result on exercise capacity and pulmonary haemodynamics,and improves WHO functional class.
