CAJ | 학술논문

热熔挤出(HME)技术是一种增加难溶性药物生物利用度的有效方法,通过形成无定形固体分散体(ASD)在显微结构上促进药物的溶出. 本文基于HME技术的研究现状,就其原料药物与聚合物载体的筛选、工艺可行性评估以及制备过程中的关键操作参数控制等方面进行了综述.
열용제출(HME)기술시일충증가난용성약물생물이용도적유효방법,통과형성무정형고체분산체(ASD)재현미결구상촉진약물적용출. 본문기우HME기술적연구현상,취기원료약물여취합물재체적사선、공예가행성평고이급제비과정중적관건조작삼수공제등방면진행료종술.
Hot melt extrusion (HME) is an effective method to make the drugs form amorphous solid dispersions (ASD) in microstructure, through which we can improve the dissolution behavior so as to improve the bioavailability of hydrophobic drugs. This review mainly focuses on the screening of active pharmaceutical ingredients and polymer carriers, feasibility evaluation of the technique, and the control of key parameters of preparation process, summarizes the application of HME to develop drug delivery system.