国际药学研究杂志
國際藥學研究雜誌
국제약학연구잡지
Journal of International Pharmaceutical Research
2015年
5期
630-633
,共4页
李姝靓%孙磊%乔善义%常新全%杨桂秋
李姝靚%孫磊%喬善義%常新全%楊桂鞦
리주정%손뢰%교선의%상신전%양계추
威麦宁硫解产物%儿茶素类化合物巯乙胺基取代物%制备
威麥寧硫解產物%兒茶素類化閤物巰乙胺基取代物%製備
위맥저류해산물%인다소류화합물구을알기취대물%제비
thiolysis products of Weimaining%cysteamine group substitutes of catechin compounds%preparation
目的 以威麦宁原料药为起始原料,制备儿茶素类化合物巯乙胺基取代物. 方法 以盐酸巯乙胺为硫解试剂,将威麦宁原料药硫解后,采用C18常压柱色谱分离结合半制备高效液相色谱分离的方法制备儿茶素类化合物巯乙胺基取代物. 结果 制备得到4β-(2-氨基乙硫基)儿茶素(Cya-Cat)、4β-(2-氨基乙硫基)表儿茶素(Cya-EC)、4β-(2-氨基乙硫基)表儿茶素没食子酸酯(Cya-ECG),纯度均≥95%. 讨论 该方法步骤简单,操作简便,为儿茶素类化合物巯乙胺基取代物的制备提供了参考.
目的 以威麥寧原料藥為起始原料,製備兒茶素類化閤物巰乙胺基取代物. 方法 以鹽痠巰乙胺為硫解試劑,將威麥寧原料藥硫解後,採用C18常壓柱色譜分離結閤半製備高效液相色譜分離的方法製備兒茶素類化閤物巰乙胺基取代物. 結果 製備得到4β-(2-氨基乙硫基)兒茶素(Cya-Cat)、4β-(2-氨基乙硫基)錶兒茶素(Cya-EC)、4β-(2-氨基乙硫基)錶兒茶素沒食子痠酯(Cya-ECG),純度均≥95%. 討論 該方法步驟簡單,操作簡便,為兒茶素類化閤物巰乙胺基取代物的製備提供瞭參攷.
목적 이위맥저원료약위기시원료,제비인다소류화합물구을알기취대물. 방법 이염산구을알위류해시제,장위맥저원료약류해후,채용C18상압주색보분리결합반제비고효액상색보분리적방법제비인다소류화합물구을알기취대물. 결과 제비득도4β-(2-안기을류기)인다소(Cya-Cat)、4β-(2-안기을류기)표인다소(Cya-EC)、4β-(2-안기을류기)표인다소몰식자산지(Cya-ECG),순도균≥95%. 토론 해방법보취간단,조작간편,위인다소류화합물구을알기취대물적제비제공료삼고.
Objective To prepare cysteamine group substitutes of catechin compounds from Weimaining. Methods After thiolased by cysteamine, Weimaining was subjected to the open column chromatography on C18, and subsequently to the semi-preparative high performance liquid chromatograph (HPLC) to prepare the cysteamine group substitutes of catechin compounds. Results Compounds 4β-(2-aminoethylthio)catechin, 4β-(2-aminoethylthio)epicatechin, and 4β-(2-aminoethylthio) epicatechin-3-O-gallate were obtained, and their purities were above 95%. Conclusion The method is simple and easy, and provides a reference for the preparation of the cysteamine group substitutes of catechin compounds.
