国际药学研究杂志
國際藥學研究雜誌
국제약학연구잡지
Journal of International Pharmaceutical Research
2015年
5期
621-624
,共4页
苏红专%胡文弋%谢彦兵%李海兵%艾凌艳
囌紅專%鬍文弋%謝彥兵%李海兵%艾凌豔
소홍전%호문익%사언병%리해병%애릉염
急性脑损伤%质子核磁共振谱图%海马%神经递质紊乱
急性腦損傷%質子覈磁共振譜圖%海馬%神經遞質紊亂
급성뇌손상%질자핵자공진보도%해마%신경체질문란
acute brain injury%1H NMR spectra%hippocampus%disorder of neurotransmitter
目的 通过检测急性脑损伤大鼠(ABI)海马核磁共振(NMR)氢谱的改变来揭示其代谢轮廓的变化. 方法 SD大鼠通过外伤造成ABI模型,收集大鼠的海马并进行NMR分析. 结果 与对照组大鼠相比,ABI组大鼠的海马代谢轮廓明显不同,谷氨酸(P<0.01)、牛磺酸(P<0.05)、肌醇(P<0.05)、谷氨酰胺(P<0.05)等代谢产物出现了显著变化. 结论 代谢组学结果表明,ABI发生时,海马内神经递质代谢出现了紊乱,这为进一步治愈ABI提供了思路.
目的 通過檢測急性腦損傷大鼠(ABI)海馬覈磁共振(NMR)氫譜的改變來揭示其代謝輪廓的變化. 方法 SD大鼠通過外傷造成ABI模型,收集大鼠的海馬併進行NMR分析. 結果 與對照組大鼠相比,ABI組大鼠的海馬代謝輪廓明顯不同,穀氨痠(P<0.01)、牛磺痠(P<0.05)、肌醇(P<0.05)、穀氨酰胺(P<0.05)等代謝產物齣現瞭顯著變化. 結論 代謝組學結果錶明,ABI髮生時,海馬內神經遞質代謝齣現瞭紊亂,這為進一步治愈ABI提供瞭思路.
목적 통과검측급성뇌손상대서(ABI)해마핵자공진(NMR)경보적개변래게시기대사륜곽적변화. 방법 SD대서통과외상조성ABI모형,수집대서적해마병진행NMR분석. 결과 여대조조대서상비,ABI조대서적해마대사륜곽명현불동,곡안산(P<0.01)、우광산(P<0.05)、기순(P<0.05)、곡안선알(P<0.05)등대사산물출현료현저변화. 결론 대사조학결과표명,ABI발생시,해마내신경체질대사출현료문란,저위진일보치유ABI제공료사로.
Objective To reveal the alterations of metabolic profiles by detecting changes in hippocampus 1H NMR spectra in acute brain injury (ABI) rats. Methods The model of ABI was achieved by trauma, and 2 hours after modeling, the hippocampus samples were collected for NMR analysis. Results Compared to age-matched control rats, the ABI rats exhibited markedly different metabolic profiles, which showed significant changes in glutamate(P<0.01), taurine(P<0.05), myo-inositol(P<0.05), and glutamine(P<0.05). Conclusion The metabonomics results suggest that amino acid metabolism is disordered when ABI occurs. This study provides clues for further understanding to cure ABI.
