CAJ | 학술논문

目的:研究美洲大蠊脱脂膏(PAE)对正常小鼠和环磷酰胺造成的免疫低下小鼠免疫功能的影响.方法:对C57BL/6小鼠腹腔注射环磷酰胺制备免疫低下模型,PAE高、中、低剂量(4 g/kg,2 g/kg,1 g/kg)灌胃15 d,测定各组的T、B淋巴细胞的增殖能力,脏器质量和脏器指数,外周血细胞数目,骨髓有核细胞计数等.结果:PAE可以促进脾淋巴细胞的增殖功能,提高免疫低下小鼠的脏器质量和脏器指数,改善其外周血象,以及增加骨髓有核细胞的数目从而提高其免疫功能.结论:PAE可以改善免疫低下小鼠的免疫功能,而对正常小鼠的免疫功能几乎没有作用.
목적:연구미주대렴탈지고(PAE)대정상소서화배린선알조성적면역저하소서면역공능적영향.방법:대C57BL/6소서복강주사배린선알제비면역저하모형,PAE고、중、저제량(4 g/kg,2 g/kg,1 g/kg)관위15 d,측정각조적T、B림파세포적증식능력,장기질량화장기지수,외주혈세포수목,골수유핵세포계수등.결과:PAE가이촉진비림파세포적증식공능,제고면역저하소서적장기질량화장기지수,개선기외주혈상,이급증가골수유핵세포적수목종이제고기면역공능.결론:PAE가이개선면역저하소서적면역공능,이대정상소서적면역공능궤호몰유작용.
Objective: To research the effect of Periplaneta americana de-fat extract on immune function in normal mice and in immunocompromised mice caused by cyclophosphamide. Methods:In this study, immunosuppressive model was established in C57BL/6 mice by cyclophosphamide. After the high, medium and low dose(4 g/kg, 2 g/kg, 1 g/kg)of P. americana de-fat extract were orally administered for 15 d, T and B lymphocyte proliferation was measured. And the organ weights and organ index, the number and classification of peripheral blood cell, bone marrow nucleated cell were tested. Results:P. americana extract can promote the peoliferrative function of splenic linphocytes, increase the weight of immunocompromised mice organs and organ index, improve their peripheral blood, and increase the number of bone marrow cells to enhance their immune function. Conclusion:The P. americana de-fat extract can improve and influence the immune function on immunocompromised mice, but it has no effect on the immune function of normal mice.