CAJ | 학술논문

目的:建立大理地区妊娠期特异的甲状腺功能正常参考值,分析其变化规律及临床意义.方法:运用Roche e601全自动电化学发光免疫分析仪,对大理地区育龄期妇女及妊娠期妇女进行血清FT3、FT4、TSH、TPOAb和TgAb检测,并参照美国国家临床生化学院(NACB)推荐的标准,筛选出正常育龄期妇女161例,正常单胎妊娠期妇女696例,其中早孕期(T1)228例,中孕期(T2)344例,晚孕期(T3)124例,对其检测结果进行统计分析,建立妊娠期特异的甲状腺功能参考值.结果:大理地区正常妊娠妇女T1、T2、T3血清FT3的均值及95%参考值范围分别为:[4.86(3.69~6.02)]pmol/L、[4.49(3.16~5.84)]pmol/L、[3.83 (2.33~5.32)]pmol/L;血清FT4的均值及95%参考值范围分别为:[17.01(12.25~21.77)]pmol/L、[14.08( 9.65~18.51)]pmol/L、[12.53(7.62~17.43)]pmol/L;血清TSH的中位数及95%参考值范围分别为:[2.12(0.37~5.60)]mIU/L、[2.31(0.39~5.09)] mIU/L、〔2.52(0.39~5.15)〕mIU/L.妊娠期妇女甲状腺功能参考值与育龄期妇女甲状腺功能参考值明显不同.结论:建立大理地区妊娠期特异的甲状腺功能正常参考值,对该地区妊娠期甲状腺功能异常的诊断有重要意义.
목적:건립대리지구임신기특이적갑상선공능정상삼고치,분석기변화규률급림상의의.방법:운용Roche e601전자동전화학발광면역분석의,대대리지구육령기부녀급임신기부녀진행혈청FT3、FT4、TSH、TPOAb화TgAb검측,병삼조미국국가림상생화학원(NACB)추천적표준,사선출정상육령기부녀161례,정상단태임신기부녀696례,기중조잉기(T1)228례,중잉기(T2)344례,만잉기(T3)124례,대기검측결과진행통계분석,건립임신기특이적갑상선공능삼고치.결과:대리지구정상임신부녀T1、T2、T3혈청FT3적균치급95%삼고치범위분별위:[4.86(3.69~6.02)]pmol/L、[4.49(3.16~5.84)]pmol/L、[3.83 (2.33~5.32)]pmol/L;혈청FT4적균치급95%삼고치범위분별위:[17.01(12.25~21.77)]pmol/L、[14.08( 9.65~18.51)]pmol/L、[12.53(7.62~17.43)]pmol/L;혈청TSH적중위수급95%삼고치범위분별위:[2.12(0.37~5.60)]mIU/L、[2.31(0.39~5.09)] mIU/L、〔2.52(0.39~5.15)〕mIU/L.임신기부녀갑상선공능삼고치여육령기부녀갑상선공능삼고치명현불동.결론:건립대리지구임신기특이적갑상선공능정상삼고치,대해지구임신기갑상선공능이상적진단유중요의의.
Objective: To establish and analyse the specific reference value of thyroid function of pregnant women in Dali area. Methods: The serum samples of women of childbearing age and pregnant women in Dali area are collected and tested for FT 3, FT4, TSH, TPOAb and TgAb by Roche Elecsys e601, then 161 women of childbearing age and 696 cases of singleton pregnant women which consist of 228 cases in early pregnancy(T1), 344 cases in middle pregnancy(T2), and 124 cases in late pregnancy(T3)are selected according to the National Institute of Clinical Biochemical (NACB) . The test results were statistically analyzed to establish the specific reference value of thyroid function in pregnancy. Results:The specific reference ranges of the FT3 are:T1 [4.86(3.69~6.02)] pmol/L, T2 [4.49 (3.16~5.84)] pmol/L, T3 [3.83 (2.33~5.32)] pmol/L; the FT4 are: T1 [17.01 (12.25~21.77)] pmol/L, T2 [14.08 (9.65~18.51)] pmol/L, T3 [12.53(7.62~17.43)] pmol/L;the TSH are:T1 [2.12(0.37~5.60)] mIU/L, T2 [2.31(0.39~5.09)] mIU/L, T3 [ 2.52(0.39~5.15)] mIU/L. The reference range of thyroid function of pregnant woman is obviously different from that of the normal woman of childbearing age in the same area. Conclusion:To establish the specific reference range of the thyroid function of pregnant woman in Dali area is significant for diagnosing the abnormal thyroid function of pregnant woman.