CAJ | 학술논문

多柔比星(DOX)的临床应用受到潜在的致命心脏毒性的限制. 增强DOX的抗癌作用同时减少相关的心脏毒性一直是近年来研究的热点.目前可能的方法包括使用心脏保护药物、DOX衍生物以及改变给药方式.本文结合近年来的研究进展提出防治DOX心脏毒性的新思路,试图找到既能发挥抗癌功效、又能起到心脏保护作用的靶点和药物.
다유비성(DOX)적림상응용수도잠재적치명심장독성적한제. 증강DOX적항암작용동시감소상관적심장독성일직시근년래연구적열점.목전가능적방법포괄사용심장보호약물、DOX연생물이급개변급약방식.본문결합근년래적연구진전제출방치DOX심장독성적신사로,시도조도기능발휘항암공효、우능기도심장보호작용적파점화약물.
The utilization of d oxorubicin (DOX) is compromised by potential lethal cardiotoxicity in clinical application. Improving DOX efficacy in cancer cells while minimizing DOX-associated cardiotoxicity is in the forefront of research. Available methods at present include cardioprotective agents, DOX derivates and dosage schedules. This paper proposes new ideas on potential drug targets aiming at enhancing cancer therapy and cardioprotection simultaneously.