CAJ | 학술논문

炎症状态与人类大多数疾病密切相关.炎症导致药物代谢酶表型的改变可影响药物在体内的代谢和处置,进而影响药效,特别是可增加药物不良反应的风险.近年来研究已证实,炎性因子水平的升高与包括Ⅰ相、Ⅱ相代谢酶在内的多种药物代谢酶的下调有密切关系, 涉及的机制不仅包括炎性细胞因子的释放,还包括与炎症相关信号通路的调控、药物代谢酶转录(后)水平的调控等.本文系统回顾了炎症状态下多种药物代谢酶表达水平和活性的变化及其相关机制,期望在疾病状态下,为根据药物代谢酶表型的个体化安全用药提供信息和研究思路.
염증상태여인류대다수질병밀절상관.염증도치약물대사매표형적개변가영향약물재체내적대사화처치,진이영향약효,특별시가증가약물불량반응적풍험.근년래연구이증실,염성인자수평적승고여포괄Ⅰ상、Ⅱ상대사매재내적다충약물대사매적하조유밀절관계, 섭급적궤제불부포괄염성세포인자적석방,환포괄여염증상관신호통로적조공、약물대사매전록(후)수평적조공등.본문계통회고료염증상태하다충약물대사매표체수평화활성적변화급기상관궤제,기망재질병상태하,위근거약물대사매표형적개체화안전용약제공신식화연구사로.
Inflammatory conditions are associated with most diseases. Phenoconversion of drug-metabolizing enzymes(DME) leads to altered drug metabolism and disposition. It has profound impact on the pharmacotherapy of widely used clinically relevant medications in terms of safety and efficacy. More and more evidence has proved that elevated levels of proinflammatory cytokines may downregulate the expression and the activity of many Phase Ⅰ and Phase Ⅱ DME, which are involved in complex regulation mechanisms of drug disposition. The aim of this review is to present the recent findings in this area. Clinical practice based on personalized medicine according to DME phenotype with improved safety and efficiency can yield robust efficacy outcomes of drug treatment and has promising future prospects.