CAJ | 학술논문

动脉粥样硬化及其所引起的心肌梗死、脑卒中、冠状动脉粥样硬化性心脏病(冠心病)等是导致老年人病死率增加的重要原因。 DNA损伤是激活DNA损伤修复路径导致细胞早衰的重要原因，而动脉粥样硬化中存在DNA损伤及DNA损伤修复机制参与的证据。糖尿病作为心血管疾病危险因素具有导致DNA损伤，从而加速血管老化的作用。该文综述了动脉粥样硬化疾病中DNA损伤和DNA双链损伤修复机制的研究进展，从而为防治动脉粥样硬化疾病提供新的思路。
동맥죽양경화급기소인기적심기경사、뇌졸중、관상동맥죽양경화성심장병(관심병)등시도치노년인병사솔증가적중요원인。 DNA손상시격활DNA손상수복로경도치세포조쇠적중요원인，이동맥죽양경화중존재DNA손상급DNA손상수복궤제삼여적증거。당뇨병작위심혈관질병위험인소구유도치DNA손상，종이가속혈관노화적작용。해문종술료동맥죽양경화질병중DNA손상화DNA쌍련손상수복궤제적연구진전，종이위방치동맥죽양경화질병제공신적사로。
Atherosclerosis and the subsequent cardiovascular complications such as myocardial infarc-tion,stroke,and coronary atherosclerotic heart disease are major causes of death among the elderly. DNA damage is the cause of the activation of the DNA damage repair pathway resulting in cell senescence,and the evidence that DNA damage and DNA damage repair mechanism participate in the process of atherosclerosis has been found in some studies. Diabetes,as a risk factor of cardiovascular disease,can lead to DNA damage, so as to accelerate the aging of blood vessels. Here is to make a review of the research development of DNA damage and DNA double strand damage repair mechanism,to provide a new method to prevent and treat ath-erosclerosis.