CAJ | 학술논문

代谢综合征( MS)会增加2型糖尿病、心血管疾病等的发病风险，在全球范围，发病率显著升高。阐明MS的基本病理过程对防治该病具有重要意义。慢性低水平炎症反应是导致MS的重要病理过程，而免疫球蛋白在炎症反应的发生发展中所起的作用逐渐受到关注。该文收集并评估了6项横断面研究和2项手术后随访研究，这些研究中多数结果表明MS患者血清免疫球蛋白( IgA、IgG、IgM)水平升高，提示免疫球蛋白在MS的发生、发展过程中扮演着重要的角色。
대사종합정( MS)회증가2형당뇨병、심혈관질병등적발병풍험，재전구범위，발병솔현저승고。천명MS적기본병리과정대방치해병구유중요의의。만성저수평염증반응시도치MS적중요병리과정，이면역구단백재염증반응적발생발전중소기적작용축점수도관주。해문수집병평고료6항횡단면연구화2항수술후수방연구，저사연구중다수결과표명MS환자혈청면역구단백( IgA、IgG、IgM)수평승고，제시면역구단백재MS적발생、발전과정중분연착중요적각색。
Metabolic syndrome ( MS) predisposes to some chronic diseases such as diabetes and cardio-vascular diseases. The prevalence of MS is increasing at alarming rates globally. The elucidation on the basic pathogenesis of MS is of great significance for the prevention and treatment. Chronic low-grade inflammation is thought to be an important pathogenesis resulting in MS, while the role of immunoglobulins in chronic inflammation is gradually paid attention to. Here we include 6 cross-sectional studies and 2 prospective stud-ies,which show the elevated levels of serum immunoglobulins (IgA,IgG,IgM) in MS patients,suggesting that the immunoglobulins may play a critical role in the initiation and development of MS.