医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
19期
3585-3588
,共4页
肺结核%白细胞介素1β%基因多态性%易患性%Meta分析
肺結覈%白細胞介素1β%基因多態性%易患性%Meta分析
폐결핵%백세포개소1β%기인다태성%역환성%Meta분석
Tuberculosis%Interleukin 1β%Polymorphism%Susceptibility%Meta-analysis
目的：探讨高加索人种白细胞介素(IL)1β+3953位点基因多态性与肺结核易患性关系。方法计算机检索数据库,收集有关高加索人种IL-1β+3953位点基因多态性与肺结核病易患性关系病例对照研究,提取纳入文献的相关数据进行Meta分析,以病例组与对照组IL-1β+3953位点各种基因模型的比值比为效应指标。结果共6篇研究符合纳入标准,累计病例数1024例,对照组995例。 Meta分析表明,IL-1β+3953位点基因多态性与肺结核病易患性无明显关联性( CC比TT：OR=0．66,95%CI 0．40~1．09,P=0．11；TC比TT：OR=0．94,95%CI 0．75~1．18,P=0．59；CC+TC比TT：OR=0．89,95%CI 0．72~1．10,P=0．30；CC 比 TC+TT：OR=0．66,95%CI 0．40~1．07,P=0．09)。结论高加索人种IL-1β+3953位点基因多态性与肺结核病易患性无明显关联性。
目的：探討高加索人種白細胞介素(IL)1β+3953位點基因多態性與肺結覈易患性關繫。方法計算機檢索數據庫,收集有關高加索人種IL-1β+3953位點基因多態性與肺結覈病易患性關繫病例對照研究,提取納入文獻的相關數據進行Meta分析,以病例組與對照組IL-1β+3953位點各種基因模型的比值比為效應指標。結果共6篇研究符閤納入標準,纍計病例數1024例,對照組995例。 Meta分析錶明,IL-1β+3953位點基因多態性與肺結覈病易患性無明顯關聯性( CC比TT：OR=0．66,95%CI 0．40~1．09,P=0．11；TC比TT：OR=0．94,95%CI 0．75~1．18,P=0．59；CC+TC比TT：OR=0．89,95%CI 0．72~1．10,P=0．30；CC 比 TC+TT：OR=0．66,95%CI 0．40~1．07,P=0．09)。結論高加索人種IL-1β+3953位點基因多態性與肺結覈病易患性無明顯關聯性。
목적：탐토고가색인충백세포개소(IL)1β+3953위점기인다태성여폐결핵역환성관계。방법계산궤검색수거고,수집유관고가색인충IL-1β+3953위점기인다태성여폐결핵병역환성관계병례대조연구,제취납입문헌적상관수거진행Meta분석,이병례조여대조조IL-1β+3953위점각충기인모형적비치비위효응지표。결과공6편연구부합납입표준,루계병례수1024례,대조조995례。 Meta분석표명,IL-1β+3953위점기인다태성여폐결핵병역환성무명현관련성( CC비TT：OR=0．66,95%CI 0．40~1．09,P=0．11；TC비TT：OR=0．94,95%CI 0．75~1．18,P=0．59；CC+TC비TT：OR=0．89,95%CI 0．72~1．10,P=0．30；CC 비 TC+TT：OR=0．66,95%CI 0．40~1．07,P=0．09)。결론고가색인충IL-1β+3953위점기인다태성여폐결핵병역환성무명현관련성。
Objective To explore the association between the interleukin 1β( IL-1β) gene +3953 pol-ymorphism and tuberculosis susceptibility in Caucasian population. Methods Data bases were comprehen-sively searched to retrace all the related studies on the associations between IL-1β gene +3953 polymor-phism and tuberculosis susceptibility in European population. The related data were extracted from the litera-ture to carry on the Meta-analysis. The pooled odds ratios( ORs) of the association between IL-1βgene+3953 polymorphism and tuberculosis susceptibility in Caucasian population were performed in different genetic model comparison. Results Altogether 6 original studies with a total of 2019 subjects(1024 patients and 995 controls) were entered the final data combination. The results of Meta-analysis showed that there were no significant associations between IL-1β gene +3953 polymorphism and tuberculosis susceptibility in Cauca-sian population [CC vs TT:OR=0. 66,95%CI 0. 40-1. 09,P=0. 11;TC vs TT:OR=0. 94,95%CI 0. 75-1. 18,P=0. 59;CC+TC vs TT:OR=0. 89,95%CI 0. 72-1. 10,P=0. 30;CC vs TC+TT:OR=0. 66,95%CI 0. 40-1. 07,P=0. 09]. Conclusion There are no significant associations between IL-1β gene +3953 polymorphism and tuberculosis susceptibility in Caucasian population.
