中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
28期
139-141
,共3页
牛磺酸熊去氧胆酸%慢性乙型肝炎%戊型肝炎%临床疗效
牛磺痠熊去氧膽痠%慢性乙型肝炎%戊型肝炎%臨床療效
우광산웅거양담산%만성을형간염%무형간염%림상료효
Tauroursodeoxycholic acid%Chronic hepatitis B%Hepatitis E%Clinical effect
目的：探讨牛磺酸熊去氧胆酸治疗慢性乙型肝炎重叠戊型肝炎病毒(HEV)感染的临床疗效。方法选取2012年11月~2014年12月我院收治的108例慢性乙型肝炎重叠戊型肝炎患者，将其按随机分为观察组和对照组，各54例。观察组采用牛磺熊去氧胆酸进行治疗，对照组采用拉米夫定进行治疗，观察记录两组患者的临床疗效及肝功能的血清总胆红素(TBiL)、碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)等指标。结果观察组患者治疗有效率为96.30%，显著高于对照组的64.81%，差异有统计学意义(P<0.05)。治疗6个月后，两组患者的肝功能各项指标明显下降，且观察组的各项指标低于对照组，差异有统计学意义(P<0.05)。观察组不良反应发生率3.7%；低于对照组的9.3%，差异有统计学意义(P<0.05)。结论采取牛磺酸熊去氧胆酸治疗慢性乙型肝炎重叠戊型肝炎的临床效果显著，有利于改善患者的肝功能指标，促进肝功能恢复，减少不良反应发生率，值得临床推广。
目的：探討牛磺痠熊去氧膽痠治療慢性乙型肝炎重疊戊型肝炎病毒(HEV)感染的臨床療效。方法選取2012年11月~2014年12月我院收治的108例慢性乙型肝炎重疊戊型肝炎患者，將其按隨機分為觀察組和對照組，各54例。觀察組採用牛磺熊去氧膽痠進行治療，對照組採用拉米伕定進行治療，觀察記錄兩組患者的臨床療效及肝功能的血清總膽紅素(TBiL)、堿性燐痠酶(ALP)、丙氨痠氨基轉移酶(ALT)、天門鼕氨痠氨基轉移酶(AST)等指標。結果觀察組患者治療有效率為96.30%，顯著高于對照組的64.81%，差異有統計學意義(P<0.05)。治療6箇月後，兩組患者的肝功能各項指標明顯下降，且觀察組的各項指標低于對照組，差異有統計學意義(P<0.05)。觀察組不良反應髮生率3.7%；低于對照組的9.3%，差異有統計學意義(P<0.05)。結論採取牛磺痠熊去氧膽痠治療慢性乙型肝炎重疊戊型肝炎的臨床效果顯著，有利于改善患者的肝功能指標，促進肝功能恢複，減少不良反應髮生率，值得臨床推廣。
목적：탐토우광산웅거양담산치료만성을형간염중첩무형간염병독(HEV)감염적림상료효。방법선취2012년11월~2014년12월아원수치적108례만성을형간염중첩무형간염환자，장기안수궤분위관찰조화대조조，각54례。관찰조채용우광웅거양담산진행치료，대조조채용랍미부정진행치료，관찰기록량조환자적림상료효급간공능적혈청총담홍소(TBiL)、감성린산매(ALP)、병안산안기전이매(ALT)、천문동안산안기전이매(AST)등지표。결과관찰조환자치료유효솔위96.30%，현저고우대조조적64.81%，차이유통계학의의(P<0.05)。치료6개월후，량조환자적간공능각항지표명현하강，차관찰조적각항지표저우대조조，차이유통계학의의(P<0.05)。관찰조불량반응발생솔3.7%；저우대조조적9.3%，차이유통계학의의(P<0.05)。결론채취우광산웅거양담산치료만성을형간염중첩무형간염적림상효과현저，유리우개선환자적간공능지표，촉진간공능회복，감소불량반응발생솔，치득림상추엄。
Objective To explore the clinical effect of tauroursodeoxycholic tauroursodeoxycholic acid acid in treatment of chronic hepatitis B overlapping hepatitis E virus (HEV) infection. Methods 108 patients with chronic hepatitis B overlapping HEV infection admitted into our hospital from November 2012 to December 2014 were selected.They were divided into control group and observation group in random,and each group was 54 cases.The observation group was treated with tauroursodeoxycholic acid,control group was treated with lamivudine.Clinical effect and TBiL,ALP,ALT and AST of liver function in two groups were observed. Results The effective rate in observation group was 96.3%,which was significantly higherthan 64.81% of control group,and the difference was statistical significance (P<0.05).After treat-ment for 6 months,index of liver function in two groups decreased obvious,the index of liver function in observation group was lower than those of control group,and the difference was statistical significance(P<0.05).The incidence of ad-verse reaction in observation group was 3.7%,which was significantly lower than 9.3% of control group,and the differ-ence was statistical significance (P<0.05). Conclusion The clinical effect is obvious by using tauroursodeoxycholic acid in treatment of chronic hepatitis B overlapping HEV infection.It is helpful to improve patients with liver function index, promote the recovery of liver function and reduce the rate of adverse reaction,worth to popularize in clinical.
