CAJ | 학술논문

目的：观察不同剂量131I在治疗甲状腺功能亢进症中的临床效果。方法选取2010年1月~2013年11月在本院就诊的64例弥漫性甲状腺肿伴甲亢患者为研究对象,将其随机分为小剂量组和常规剂量组,各32例。小剂量组给予50~80μCi/g甲状腺组织的131I,多次重复使用；常规剂量组一次性口服100~120μCi/g甲状腺组织的131I。比较两组患者治疗前后血清FT3、FT4、TSH水平、临床疗效及甲减发生率。结果治疗前,两组血清FT3、FT4、TSH水平均未见显著性差异(P>0.05)；治疗后,两组FT3、FT4水平较治疗前显著下降,TSH较治疗前显著上升,前后差异有统计学意义(P<0.05),但治疗后两组的三项指标水平无显著性差异(P>0.05)。小剂量组的治疗有效率为96.9%,常规剂量组为100.0%,两组的治疗有效率未见显著性差异(P>0.05)。治疗1年后,小剂量组甲减发生率为3.1%,常规剂量组为18.8%,小剂量组的甲减发生率低于常规剂量组,差异有显著性(P<0.05)。结论采用小剂量131I治疗甲状腺功能亢进症的临床疗效好、甲减发生率低。
목적：관찰불동제량131I재치료갑상선공능항진증중적림상효과。방법선취2010년1월~2013년11월재본원취진적64례미만성갑상선종반갑항환자위연구대상,장기수궤분위소제량조화상규제량조,각32례。소제량조급여50~80μCi/g갑상선조직적131I,다차중복사용；상규제량조일차성구복100~120μCi/g갑상선조직적131I。비교량조환자치료전후혈청FT3、FT4、TSH수평、림상료효급갑감발생솔。결과치료전,량조혈청FT3、FT4、TSH수평균미견현저성차이(P>0.05)；치료후,량조FT3、FT4수평교치료전현저하강,TSH교치료전현저상승,전후차이유통계학의의(P<0.05),단치료후량조적삼항지표수평무현저성차이(P>0.05)。소제량조적치료유효솔위96.9%,상규제량조위100.0%,량조적치료유효솔미견현저성차이(P>0.05)。치료1년후,소제량조갑감발생솔위3.1%,상규제량조위18.8%,소제량조적갑감발생솔저우상규제량조,차이유현저성(P<0.05)。결론채용소제량131I치료갑상선공능항진증적림상료효호、갑감발생솔저。
Objective To observe the clinical effects of different dosage of 131I in the treatment of hyperthyroidism. Methods 64 patients with diffuse goiter associated with hyperthyroidism treated in our hospital from January 2010 to November 2013 were selected and randomly divided into small-dose group and standard-dose group,32 cases in each group.Small-dose group was given 50 to 80μCi/g thyroid tissue 131I,repeated use.Standard-dose group was taken 100 to 120 μCi/g thyroid tissue 131I in the conventional dose group by once orally.The levels of FT3,FT4 and TSH as well as clinical efficacy and incidence of hypothyroidism in two groups before and after treatment were compared. Results Be-fore treatment,the levels of FT3, FT4 and TSH of two groups were not significantly different (P>0.05).After treatment,the levels of FT3 and FT4 of two groups were significantly lower than before,and the level of TSH was significantly higher than before(P<0.05),the differences was significant before and after treatment(P<0.05),but the level of three indicators in two groups were not significantly differents (P>0.05).The effective rate of treatment in small-dose group was 96.9%,in standard-dose group was 100.0%,the difference was not significant between two groups (P>0.05).After 1 year of treat-ment,the incidence of hypothyroidism insmall-dose group was 3.1%,which was lower than 18.8% of standard-dose group,the difference was significant (P<0.05). Conclusion The small dosage of 131I has a good clinical effect in the hy-perthyroidism and reduces the incidence of hypothyroidism.