CAJ | 학술논문

目的：分析并评价2型糖尿病伴高尿酸血症的临床特点。方法选取2012年1月至2013年3月清苑县人民医院收治的480例2型糖尿病患者,根据血尿酸水平分为糖尿病伴高尿酸血症组(280例)和糖尿病正常血尿酸组(200例),比较两组患者的空腹血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹胰岛素水平以及并发症发生情况。结果糖尿病伴高尿酸血症组患者空腹血糖、糖化血红蛋白水平与糖尿病正常血尿酸组比较差异无统计学意义( P>0．05)；总胆固醇、三酰甘油、低密度脂蛋白胆固醇、空腹胰岛素水平显著高于糖尿病正常血尿酸组[(5．4±1．0) mmol/L 比(4．8±1．1) mmol/L,(2．4±1．1) mmol/L 比(1．5±1．0) mmol/L,(3．4±1．0) mmol/L比(2．8±0．9) mmol/L,(16．2±3．5) mU/L比(11．4±3．1) mU/L, P<0．01],高密度脂蛋白胆固醇显著低于糖尿病正常血尿酸组[(1．0±0．4) mmol/L 比(1．2±0．5) mmol/L,P<0．01]。糖尿病伴高尿酸血症组患者冠心病、高血压、脑卒中的发生率显著高于糖尿病正常血尿酸组[49．3%(138/280)比27．5%(55/200),61．8%(173/280)比43．0%(86/200),26．4%(74/280)比14．5%(29/200),P<0．01]。结论2型糖尿病患者不但要控制血糖、血脂、血压等,还应监测血尿酸水平,延缓疾病进展。
목적：분석병평개2형당뇨병반고뇨산혈증적림상특점。방법선취2012년1월지2013년3월청원현인민의원수치적480례2형당뇨병환자,근거혈뇨산수평분위당뇨병반고뇨산혈증조(280례)화당뇨병정상혈뇨산조(200례),비교량조환자적공복혈당、당화혈홍단백、총담고순、삼선감유、저밀도지단백담고순、고밀도지단백담고순、공복이도소수평이급병발증발생정황。결과당뇨병반고뇨산혈증조환자공복혈당、당화혈홍단백수평여당뇨병정상혈뇨산조비교차이무통계학의의( P>0．05)；총담고순、삼선감유、저밀도지단백담고순、공복이도소수평현저고우당뇨병정상혈뇨산조[(5．4±1．0) mmol/L 비(4．8±1．1) mmol/L,(2．4±1．1) mmol/L 비(1．5±1．0) mmol/L,(3．4±1．0) mmol/L비(2．8±0．9) mmol/L,(16．2±3．5) mU/L비(11．4±3．1) mU/L, P<0．01],고밀도지단백담고순현저저우당뇨병정상혈뇨산조[(1．0±0．4) mmol/L 비(1．2±0．5) mmol/L,P<0．01]。당뇨병반고뇨산혈증조환자관심병、고혈압、뇌졸중적발생솔현저고우당뇨병정상혈뇨산조[49．3%(138/280)비27．5%(55/200),61．8%(173/280)비43．0%(86/200),26．4%(74/280)비14．5%(29/200),P<0．01]。결론2형당뇨병환자불단요공제혈당、혈지、혈압등,환응감측혈뇨산수평,연완질병진전。
Objective To analyze and evaluate the clinical characteristics of tvpe 2 diabetes mellitus patients with hyperuricemia. Methods A total of 480 type 2 diabetes mellitus patients admitted to Qingyuan County people′s hospital from Jan. 2012 to Mar. 2013 were divided into two groups according to the blood uric acid level:diabetes with hypemricemia group(280 cases) and diabetes with normal blood uric acid group (200 cases). The indexes of fasting plasma glucose,glycosylated hemoglobin,total cholesterin,triacylglycerol, low density lipoprotein cholesterol,high density lipoprotein cholesterol,fasting insulin and the complication occurrence of the two groups were compared. Results There were no significant difference of fasting plasma glucose and glycosylated hemoglobin levels between the two groups(P>0. 05). The total cholesterin,triacyl-glycerol,low density lipoprotein cholesterol levels of the diabetes with hyperuricemia group were higher than that of the diabetes with normal blood uric acid group[(5. 4 ± 1. 0) mmol/L vs (4. 8 ± 1. 1) mmol/L, (2.4 ±1.1) mmol/L vs (1.5 ±1.0) mmol/L,(3.4 ±1.0) mmol/L vs (2.8 ±0.9) mmol/L,(16.2 ± 3.5)mU/Lvs(11.4±3.1)mU/L,P<0.01].Highdensitylipoproteincholesterollevelsofthediabetes with hypemricemia group was lower than that of the diabetes with normal blood uric acid group[(1. 0 ±0. 4) mmol/L vs (1. 2 ± 0. 5) mmol/L,P<0. 01]. The incidences of coronary heart disease,hypertension,and stroke of the diabetes with hyperuricemia group were significantly higher than those of normal blood uric acid group [49. 3%(138/280) vs 27. 5%(55/200),61. 8%(173/280) vs 43. 0%(86/200),26. 4%(74/280) vs 14. 5%(29/200),P<0. 01]. Conclusion The type 2 diabetes patients should not only control the blood glucose,blood lipid,and blood pressure,but also monitor the blood uric acid level in order to post-pone the progression of the disease.