CAJ | 학술논문

血红素加氧酶-1(HO-1)是一种重要的抗炎、抗凋亡、抗氧化及耐药相关基因. 在生理状态下,人体正常组织中的HO-1蛋白呈低表达. 在遭受酒精、辛辣及热烫等持续刺激时,其表达升高.HO-1的表达异常与肿瘤的生物学行为密切相关. 近年来研究发现,其基因多态性及分解血红素产生的代谢产物(胆红素、Fe2+、CO)参与的多条信号通路的激活,并影响多种肿瘤疾病的发生、发展. 另外,在许多肿瘤中HO-1表达水平上调,不仅影响肿瘤微环境中氧化应激水平对肿瘤细胞生长及增殖的调节,而且还能诱导肿瘤细胞产生耐药性. 因此,HO-1表达异常可能参与了肿瘤的发生发展.
혈홍소가양매-1(HO-1)시일충중요적항염、항조망、항양화급내약상관기인. 재생리상태하,인체정상조직중적HO-1단백정저표체. 재조수주정、신랄급열탕등지속자격시,기표체승고.HO-1적표체이상여종류적생물학행위밀절상관. 근년래연구발현,기기인다태성급분해혈홍소산생적대사산물(담홍소、Fe2+、CO)삼여적다조신호통로적격활,병영향다충종류질병적발생、발전. 령외,재허다종류중HO-1표체수평상조,불부영향종류미배경중양화응격수평대종류세포생장급증식적조절,이차환능유도종류세포산생내약성. 인차,HO-1표체이상가능삼여료종류적발생발전.
Heme oxygenase-1(HO-1)is a type of stress related gene,which harbors the ability of anti-inflammatory,anti-apoptosis,anti-oxidation and drug resistance.In physiological status,the expression of HO-1 gene in human normal tissues is extremely low.When subjected to a constant stimulation of alcohol,spicy and hot,over expression of HO-1 gene in the related tissues is often observed.In tumor tissues,the abnormal expres-sion of HO-1 is closely related to their biological behaviors.In recent years,there is a trend to believe that the gene polymorphism and its metabolic products( bilirubin,Fe2+,CO) involve in the decomposition of heme partici-pate in the activation of many signaling pathways,and affect the initiation and development of tumor diseases.In addition,the expression level of HO-1 gene is up-regulated in many tumor diseases,which can not only affect the growth and proliferation of tumor cells by regulation of the oxidative stress levels of tumor microenvironments, but also induce the tumor cells to produce drug resistance.Therefore,the abnormal expression of HO-1 may be involved in the initiation and development processes of tumors.