CAJ | 학술논문

目的：探讨核素唾液腺显像半定量分析在继发性干燥综合征(sSS)诊断中的临床价值,并与唇腺病理活检结果进行相关性分析。方法选取2007年1月~2014年1月本院收治的38例sSS患者作为研究对象,进行唾液腺显像和唇腺病理活检。唾液腺显像进行半定量分析,得出双侧腮腺、颌下腺的摄取指数(UI)、排泄指数(EF)。将sSS患者与正常对照组的唾液腺半定量指标进行对比分析,将唾液腺半定量指标与唇腺活检病理分级进行相关性分析。结果 sSS组的双侧腮腺UI、双侧颌下腺UI、双侧腮腺EF、双侧颌下腺EF显著低于正常对照组,差异有统计学意义(P<0.05)。左侧腮腺、右侧腮腺、左侧颌下腺、右侧颌下腺的EF均与病理分级呈负相关。双侧腮腺、颌下腺的UI与病理分级无相关性。结论唾液腺显像半定量分析有助于诊断sSS,且与唇腺活检病理有较好的相关性,半定量指标中的EF意义更大。
목적：탐토핵소타액선현상반정량분석재계발성간조종합정(sSS)진단중적림상개치,병여진선병리활검결과진행상관성분석。방법선취2007년1월~2014년1월본원수치적38례sSS환자작위연구대상,진행타액선현상화진선병리활검。타액선현상진행반정량분석,득출쌍측시선、합하선적섭취지수(UI)、배설지수(EF)。장sSS환자여정상대조조적타액선반정량지표진행대비분석,장타액선반정량지표여진선활검병리분급진행상관성분석。결과 sSS조적쌍측시선UI、쌍측합하선UI、쌍측시선EF、쌍측합하선EF현저저우정상대조조,차이유통계학의의(P<0.05)。좌측시선、우측시선、좌측합하선、우측합하선적EF균여병리분급정부상관。쌍측시선、합하선적UI여병리분급무상관성。결론타액선현상반정량분석유조우진단sSS,차여진선활검병리유교호적상관성,반정량지표중적EF의의경대。
Objective To explore the clinical value of nuclide salivary glands imaging semi-quantitative analysis in the diagnosis of secondary Sjogren syndrome (sSS),and to analysis the correlation with labial gland pathological biopsy results. Methods 38 cases with sSS from January 2007 to January 2014 in our hospital were selected as the research objects. All patients were conducted with salivary glands imaging and labial gland pathological biopsy.Bilateral parotid,uptake index of submandibular gland and excretion fraction were reached by using salivary glands imaging for semi-quantitative analysis.Salivary glands imaging semi-quantitative index was compared between the sSS patients and the control group.The correlation analysis was conducted between salivary glands imaging semi-quantitative index and labial gland biopsy pathology classification. Results The UI of bilateral parotid and bilateral submandibular gland,the EF of bilateral parotid and bilateral submandibular gland in the sSS group was lower than that in the normal control group,with significant difference(P<0.05).The EF of bilateral parotid and submandibular gland was negatively correlated with pathology classification.The UI of bilateral parotid and submandibular gland was irrelevant to pathology classifica-tion. Conclusion Salivary glands imaging semi-quantitative analysis is helpful to diagnosis the secondary sjogren syn-drome and has a preferably correlation with labial gland biopsy pathological.The meaning of EF in semi-quantitative in-dex is greater.