CAJ | 학술논문

目的：分析浙江省开化县219例痰涂片阳性（涂阳）肺结核病例结核分枝杆菌的耐药情况，为制订结核病控制对策提供科学依据。方法对2010年1月至2013年12月在开化县人民医院结核门诊诊治的涂阳肺结核病例的痰标本进行结核分枝杆菌培养，菌型鉴定为结核分枝杆菌的菌株采用比例法进行6种抗结核药物异烟肼、利福平、乙胺丁醇、链霉素、左氧氟沙星、卡那霉素耐药性监测。结果219例培养阳性病例中，总耐药率为21．46％，耐多药率3．20％，初始耐药率为19．69％，初始耐多药率为0．52％，获得性耐药率34．62％，获得性耐多药率23．08％。结论开化县2010至2013年结核分枝杆菌总耐药率、耐多药率、初始耐药率、初始耐多药率、获得性耐药率均低于全国第五次结核病流行病学调查结果，而获得性耐多药率则高于全国第五次结核病流行病学调查结果。
목적：분석절강성개화현219례담도편양성（도양）폐결핵병례결핵분지간균적내약정황，위제정결핵병공제대책제공과학의거。방법대2010년1월지2013년12월재개화현인민의원결핵문진진치적도양폐결핵병례적담표본진행결핵분지간균배양，균형감정위결핵분지간균적균주채용비례법진행6충항결핵약물이연정、리복평、을알정순、련매소、좌양불사성、잡나매소내약성감측。결과219례배양양성병례중，총내약솔위21．46％，내다약솔3．20％，초시내약솔위19．69％，초시내다약솔위0．52％，획득성내약솔34．62％，획득성내다약솔23．08％。결론개화현2010지2013년결핵분지간균총내약솔、내다약솔、초시내약솔、초시내다약솔、획득성내약솔균저우전국제오차결핵병류행병학조사결과，이획득성내다약솔칙고우전국제오차결핵병류행병학조사결과。
Objective To analyze the multidrug resistant situation with Mycobacterium tuberculosis in Kaihua county in order to provide technical basis for formulating measures on tuberculosis control. Methods Mycobacterium tuberculosis were cultivated, which were collected from smear positive tuberculosis patients'sputum in People's Hospital of Kaihua County from January 2010 to December 2013. Proportion method for Mycobacterium tuberculosis drug sensitivity test was conducted to 6 anti-tuberculosis drugs (isoniazide, rifampin, ethambutol, streptomycin, levofloxacin, kanamycin). Results In 219 Mycobacterium tuberculosis culture positive patients, the rate of total drug resistance was 21.46% and the rate of total multidrug resistance 3 .20%;the rate of initial drug resistance was 19 .69%, and the rate of initial multidrug resistance 0.52%;the rate of acquired drug resistance was 34.62%, and the rate of acquired multidrug resistance 23.08%. Conclusion The rate of total drug resistance, total multidrug resistance, initial drug resistance, initial multidrug resistance and acquired drug resistance are respectively less than the result of The 5th National Tuberculosis Epidemiological Survey, while the rate of acquired multidrug resistance is more than the latter.