CAJ | 학술논문

目的：比较不同浓度罗哌卡因用于术后自控镇痛的效果。方法选取本院2013年6月~2015年3月收治的240例下腹部手术患者作为研究对象，按照随机数字表法分为A组、B组和C组，各80例。 A组术后自控镇痛中采取0.125%罗哌卡因垣芬太尼，B组采取0.16%罗哌卡因垣芬太尼，C组采取0.20%罗哌卡因垣芬太尼，比较3组术后的镇痛效果。结果 A组12、24、48 h的VAS评分显著高于B组和C组，差异有统计学意义(P<0.05)。 B组与C组4、12、24、48 h的VAS评分比较，差异无统计学意义(P>0.05)。3组4、12、24、48 h的Ramsay评分比较，差异无统计学意义(P>0.05)。3组术后48 h的Bromage评分比较，差异无统计学意义(P>0.05)。 C组的不良反应发生率显著高于A组和B组，差异有统计学意义(P<0.05)。结论不同浓度罗哌卡因在术后自控镇痛中均取得显著效果，而0.16%罗哌卡因垣芬太尼术后自控镇痛效果更为显著，不良反应少。
목적：비교불동농도라고잡인용우술후자공진통적효과。방법선취본원2013년6월~2015년3월수치적240례하복부수술환자작위연구대상，안조수궤수자표법분위A조、B조화C조，각80례。 A조술후자공진통중채취0.125%라고잡인원분태니，B조채취0.16%라고잡인원분태니，C조채취0.20%라고잡인원분태니，비교3조술후적진통효과。결과 A조12、24、48 h적VAS평분현저고우B조화C조，차이유통계학의의(P<0.05)。 B조여C조4、12、24、48 h적VAS평분비교，차이무통계학의의(P>0.05)。3조4、12、24、48 h적Ramsay평분비교，차이무통계학의의(P>0.05)。3조술후48 h적Bromage평분비교，차이무통계학의의(P>0.05)。 C조적불량반응발생솔현저고우A조화B조，차이유통계학의의(P<0.05)。결론불동농도라고잡인재술후자공진통중균취득현저효과，이0.16%라고잡인원분태니술후자공진통효과경위현저，불량반응소。
Objective To compare the effect of ropivacaine with different concentration in the application for postoper-ative controlled analgesia. Methods 240 patients with lower abdominal surgery from June 2013 to March 2015 in our hospital were selected and divided into group A,group B and group C according to the random number table method,80 patients in each group.Group A was given ropivacaine (0.125%) combined with phentanyl during postoperative patient controlled analgesia,group B was given ropivacaine (0.16%) combined with phentanyl,group C was given ropivacaine (0.20%) combined with phentanyl.Postoperative analgesic effect among three groups was compared. Results The VAS score of group A in 12,24,48 h was higher than that of group B and group C,with significant difference (P<0.05).There was no significant difference of the VAS score in 4,12,24,48 h between group B and group C (P>0.05).There was no significant difference of the Ramsay score in 4,12,24,48 h among three groups (P>0.05).There was no significant differ-ence of the Bromage score after operation in 48 h among three groups (P>0.05).The incidence rate of adverse effect in group C was higher than that group A and group B,with significant difference (P<0.05). Conclusion Different concen-trations of ropivacaine have achieved remarkable effect in postoperative controlled analgesia.The effect of ropivacaine (0.16%) combined with fentanyl in postoperative controlled analgesia is more remarkable and has less adverse reaction.