CAJ | 학술논문

目的研究脑胶质瘤中CDK4和β-Catenin的表达情况及相关性. 方法采用免疫组织化学法检测45例脑胶质瘤组织和8例癌旁正常组织中CDK4和β-Catenin的表达,并将其按WHO 2000年神经系统肿瘤病理学分级标准进行分类分级,进行统计学分析. 结果 45例脑胶质瘤组织中CDK4和β-Catenin 阳性表达率分别为73.3%和77.8%,与癌旁正常组织之间的差异具有统计学意义( P <0.05).CDK4和β-Catenin的表达均与WHO分级和组织学分型相关(P<0.05),与患者性别、年龄之间差异无统计学意义(P>0.05). CDK4和β-Catenin的表达呈正相关(r=0.52,P<0.01),二者表达均阳性患者恶性程度高. 结论脑胶质瘤中CDK4和β-Catenin的表达增高可能与胶质瘤的恶性变和恶性胶质瘤的发生有关,二者相结合有望成为胶质瘤恶性评估的重要指标.
목적 연구뇌효질류중CDK4화β-Catenin적표체정황급상관성. 방법 채용면역조직화학법검측45례뇌효질류조직화8례암방정상조직중CDK4화β-Catenin적표체,병장기안WHO 2000년신경계통종류병이학분급표준진행분류분급,진행통계학분석. 결과 45례뇌효질류조직중CDK4화β-Catenin 양성표체솔분별위73.3%화77.8%,여암방정상조직지간적차이구유통계학의의( P <0.05).CDK4화β-Catenin적표체균여WHO분급화조직학분형상관(P<0.05),여환자성별、년령지간차이무통계학의의(P>0.05). CDK4화β-Catenin적표체정정상관(r=0.52,P<0.01),이자표체균양성환자악성정도고. 결론 뇌효질류중CDK4화β-Catenin적표체증고가능여효질류적악성변화악성효질류적발생유관,이자상결합유망성위효질류악성평고적중요지표.
Objective To study the expression of CDK4 andβ-Catenin and their relevance in glioma. Methods We used immunohistochemistry to detect the expression of CDK4 andβ-Catenin in forty-five glio-ma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 andβ-Catenin expressions between normal tis-sues and glioma tissues(P<0.01).The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased(P <0.05).Furthermore,the expression of CDK4 was positively correlated with the expression ofβ-Catenin in glioma(r=0.52,P<0.01).Conclusion The increased expression of CDK4 andβ-Catenin may have correlation with malignant change of glioma and oc-curance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.