中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2015年
10期
1001-1004
,共4页
刘源%郗晓婧%王增亮%吴昊%汪永新%于湘友
劉源%郗曉婧%王增亮%吳昊%汪永新%于湘友
류원%치효청%왕증량%오호%왕영신%우상우
中枢神经系统细菌感染%神经外科手术%预后%降钙素原清除率
中樞神經繫統細菌感染%神經外科手術%預後%降鈣素原清除率
중추신경계통세균감염%신경외과수술%예후%강개소원청제솔
Central nervous system bacterial infections%Neurosurgical procedures%Prognosis%Procalcitonin clearance rate
目的 研究血清降钙素原(PCT)及其清除率(PCTc)在开颅术后不同转归的颅内感染患者中的变化规律.方法 纳入2010年11月至2013年11月新疆医科大学第一附属医院神经外科经手术治疗后发生颅内感染的患者32例.根据抗生素等治疗结果将其分为死亡组(8例)和生存组(24例).检测颅内感染确诊24 h内(治疗前)及治疗后第3、5、7、9天后的PCT,计算血清PCT清除率并采用秩和检验行统计学分析.结果 生存组治疗前及抗生素治疗后第3、5、7、9天血清的PCT中位数(范围)分别为0.64(0.37 ～0.78)、0.44(0.34～0.53)、0.22(0.13～0.46)、0.20(0.95 ～0.34)、0.16(0.14～0.25) ng/ml,死亡组分别为0.46(0.30～0.93)、0.69 (0.66～0.80)、0.60(0.46 ～0.88)、0.96(0.36～1.08)、1.06(0.92 ～ 1.52) ng/ml,两组治疗前PCT差异无统计学意义,治疗后第3、5、7、9天的PCT差异有统计学意义(P＜0.01).治疗后第3、5、7天,生存组的PCT清除率分别为84.0(-29.0～123.5)、86.7(-46.9～158.8)、16.1 (11.5 ～ 135.3)％,死亡组分别为-26.5(-44.4 ～-7.0)、-61.8(-70.5 ～-29.8)、-69.1(-84.1 ～-38.7)％,治疗后第3、5、7天,两组的PCT清除率差异均有统计学意义(P＜0.01).结论 PCT的动态变化及PCT清除率能够有效预测颅内感染治疗的有效性及预后.
目的 研究血清降鈣素原(PCT)及其清除率(PCTc)在開顱術後不同轉歸的顱內感染患者中的變化規律.方法 納入2010年11月至2013年11月新疆醫科大學第一附屬醫院神經外科經手術治療後髮生顱內感染的患者32例.根據抗生素等治療結果將其分為死亡組(8例)和生存組(24例).檢測顱內感染確診24 h內(治療前)及治療後第3、5、7、9天後的PCT,計算血清PCT清除率併採用秩和檢驗行統計學分析.結果 生存組治療前及抗生素治療後第3、5、7、9天血清的PCT中位數(範圍)分彆為0.64(0.37 ～0.78)、0.44(0.34～0.53)、0.22(0.13～0.46)、0.20(0.95 ～0.34)、0.16(0.14～0.25) ng/ml,死亡組分彆為0.46(0.30～0.93)、0.69 (0.66～0.80)、0.60(0.46 ～0.88)、0.96(0.36～1.08)、1.06(0.92 ～ 1.52) ng/ml,兩組治療前PCT差異無統計學意義,治療後第3、5、7、9天的PCT差異有統計學意義(P＜0.01).治療後第3、5、7天,生存組的PCT清除率分彆為84.0(-29.0～123.5)、86.7(-46.9～158.8)、16.1 (11.5 ～ 135.3)％,死亡組分彆為-26.5(-44.4 ～-7.0)、-61.8(-70.5 ～-29.8)、-69.1(-84.1 ～-38.7)％,治療後第3、5、7天,兩組的PCT清除率差異均有統計學意義(P＜0.01).結論 PCT的動態變化及PCT清除率能夠有效預測顱內感染治療的有效性及預後.
목적 연구혈청강개소원(PCT)급기청제솔(PCTc)재개로술후불동전귀적로내감염환자중적변화규률.방법 납입2010년11월지2013년11월신강의과대학제일부속의원신경외과경수술치료후발생로내감염적환자32례.근거항생소등치료결과장기분위사망조(8례)화생존조(24례).검측로내감염학진24 h내(치료전)급치료후제3、5、7、9천후적PCT,계산혈청PCT청제솔병채용질화검험행통계학분석.결과 생존조치료전급항생소치료후제3、5、7、9천혈청적PCT중위수(범위)분별위0.64(0.37 ～0.78)、0.44(0.34～0.53)、0.22(0.13～0.46)、0.20(0.95 ～0.34)、0.16(0.14～0.25) ng/ml,사망조분별위0.46(0.30～0.93)、0.69 (0.66～0.80)、0.60(0.46 ～0.88)、0.96(0.36～1.08)、1.06(0.92 ～ 1.52) ng/ml,량조치료전PCT차이무통계학의의,치료후제3、5、7、9천적PCT차이유통계학의의(P＜0.01).치료후제3、5、7천,생존조적PCT청제솔분별위84.0(-29.0～123.5)、86.7(-46.9～158.8)、16.1 (11.5 ～ 135.3)％,사망조분별위-26.5(-44.4 ～-7.0)、-61.8(-70.5 ～-29.8)、-69.1(-84.1 ～-38.7)％,치료후제3、5、7천,량조적PCT청제솔차이균유통계학의의(P＜0.01).결론 PCT적동태변화급PCT청제솔능구유효예측로내감염치료적유효성급예후.
Objective To investigate the change regulation of the serum procalcitonin (PCT) and procalcitonin clearance (PCTc) in patients with intracranial infection in different outcomes after craniotomy.Methods A total 32 patients with intracranial infection after neurosurgical operation treated at the Department of Neurosurgery,the First Affiliated Hospital of Xinjiang Medical University from November 2010 to November 2013 were enrolled.They were divided into either a death group (n =8) or a survival group (n =24) according to the results of antibiotic and other therapies.Intracranial infection was detected and PCT was diagnosed within 24 h and at 3,5,7,and 9 days after treatment.The serum PCTc was calculated and the Wilcoxon test was used for statistical analysis.Results The PCT mass concentration in survival group were the PCT median (range) 0.64 (0.37-0.78),0.44 (0.34-0.53),0.22 (0.13-0.46),0.20 (0.95-0.34),and 0.16 (0.14-0.25)ng/ml,respectively for the first time and at the 3,5,7,and 9 days of antibiotic treatment,in the death group were 0.46 (0.30-0.93),0.69 (0.66-0.80),0.60 (0.46-0.88),0.96 (0.36-1.08),and 1.06 (0.92-1.52) ng/ml,respectively.There was no significant difference in the first PCT between the two groups.There were significant differences in PCT at 3,5,7,and 9 days after treatment (P＜0.01).At the 3,5,and 7 days of treatment,the PCT clearance rates of the survival group were 84.0 (-29.0 -123.5)％,86.7 (-46.9-158.8)％,and 16.13 (11.5-135.3)％,respectively,those of the death group were-26.5 (-44.4--7.0)％,-61.8 (-70.5--29.8)％,and-69.1 (-84.1--38.7)％,respectively.At the 3,5,and 7 days after treatment,there were significant differences in the PCT clearance rates between the two groups (P ＜ 0.01).Conclusion The PCT dynamic changes and PCT clearance rate can effectively predict the effectiveness and prognosis of intracranial infection treatment.
