CAJ | 학술논문

本文采用文献回顾的方法,对RET( Rearranged during transfection)原癌基因及编码产物的结构,参与细胞内信号的转导方式,以及RET基因与甲状腺癌、乳腺癌、肺癌关系的研究进展做一综述.RET基因编码酪氨酸激酶受体,参与细胞内信号转导,RET原癌基因重排在乳头状甲状腺癌中较常见,其在乳腺癌、肺癌中的重排研究近来受到关注. 此外,RET也是肿瘤治疗的一个有意义的靶点.
본문채용문헌회고적방법,대RET( Rearranged during transfection)원암기인급편마산물적결구,삼여세포내신호적전도방식,이급RET기인여갑상선암、유선암、폐암관계적연구진전주일종술.RET기인편마락안산격매수체,삼여세포내신호전도,RET원암기인중배재유두상갑상선암중교상견,기재유선암、폐암중적중배연구근래수도관주. 차외,RET야시종류치료적일개유의의적파점.
To review recent studies on the research advance of RET( Rearranged during transfection) on-cogene in thyroid cancer,breast cancer,and lung cancer.The literatures on the structure of RET gene and coding product,cell signal transduction,relationship among thyroid cancer,breast cancer,and lung cancer are reviewed. RET gene encoding tyrosine kinase receptor,involving in cell signal transduction,rearrangement of RET gene is frequently seen in thyroid cancer,which is reported more and more in breast cancer,and lung cancer.Rearrange-ment of RET gene is closely correlated with the occurrence and progress of thyroid cancer,breast cancer,and lung cancer.Taking together,these findings suggest that RET present an attractive therapeutic target for the treatment of certain cancer subsets.