实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
Practical Oncology Journal
2015年
5期
458-461
,共4页
DCLK1%肿瘤干细胞%消化道肿瘤%靶向治疗%预后预测
DCLK1%腫瘤榦細胞%消化道腫瘤%靶嚮治療%預後預測
DCLK1%종류간세포%소화도종류%파향치료%예후예측
DCLK1%Neoplastic stem cells%Gastrointestinal tumor%Targeted therapy%Prognosis
肿瘤干细胞标志物的发现及应用对于肿瘤的预防和治疗有重要的意义. DCLK1是首次被发现只存在于肿瘤干细胞而不存在于正常干细胞的标志物. DCLK1在胃肠道癌、食道癌、胆管癌和神经胶质瘤等肿瘤细胞中均有表达,并且与肿瘤的发生发展和迁移复发都密切相关. 尽管DCLK1作为肿瘤干细胞标志物还存在很多未知,但是DCLK1为肿瘤的靶向特异性治疗提供了一个新的发展前景.
腫瘤榦細胞標誌物的髮現及應用對于腫瘤的預防和治療有重要的意義. DCLK1是首次被髮現隻存在于腫瘤榦細胞而不存在于正常榦細胞的標誌物. DCLK1在胃腸道癌、食道癌、膽管癌和神經膠質瘤等腫瘤細胞中均有錶達,併且與腫瘤的髮生髮展和遷移複髮都密切相關. 儘管DCLK1作為腫瘤榦細胞標誌物還存在很多未知,但是DCLK1為腫瘤的靶嚮特異性治療提供瞭一箇新的髮展前景.
종류간세포표지물적발현급응용대우종류적예방화치료유중요적의의. DCLK1시수차피발현지존재우종류간세포이불존재우정상간세포적표지물. DCLK1재위장도암、식도암、담관암화신경효질류등종류세포중균유표체,병차여종류적발생발전화천이복발도밀절상관. 진관DCLK1작위종류간세포표지물환존재흔다미지,단시DCLK1위종류적파향특이성치료제공료일개신적발전전경.
The discovery and application of cancer stem cell markers have very important significance on tumor treatment and prevention.DCLK1 is discovered only in the cancer stem cell marker but not nomal stem cells for the first time.Some studies have shown that DCLK1 expression was detectded in gastrointestinal cancer,esoph-ageal cancer,bile duct carcinoma and glioma.The expression of DCLK1 in tumor is closely related to tumor devel-opment,progression,and recurrenceand migration.Although DCLK1 remain to be known as cancer stem cell mark-er,it provides a new developing prospectives for tumor targeting specific treatment.
