实用肿瘤学杂志
實用腫瘤學雜誌
실용종류학잡지
Practical Oncology Journal
2015年
5期
432-437
,共6页
血脂%远处转移%激素受体阴性%乳腺癌%疗效
血脂%遠處轉移%激素受體陰性%乳腺癌%療效
혈지%원처전이%격소수체음성%유선암%료효
Blood lipid%Distant metastases%Hormone receptor negative%Breast cancer%Clinical response
目的 测定激素受体阴性乳腺癌患者的血脂水平,探讨血脂异常与远处转移的关系,及化疗后血脂水平变化与近期疗效的关系. 方法 收集154例激素受体阴性乳腺癌患者的临床病理资料和空腹血脂水平,远处转移组患者化疗2周期后第14天再次测定血脂水平. χ2 检验分析临床病理特征及基线血脂水平与远处转移的关系,Logistic回归分析远处转移的独立危险因素,配对t检验分析远处转移组患者化疗后血脂各指标变化与疗效关系. 结果 乳腺癌远处转移与肿块大小、区域淋巴结转移、组织学分级、高TC、高TG及高LDL-C血症有关(P<0.05). Logistic回归分析显示,肿块大小(OR=1.563)、区域淋巴结转移(OR=1.983)、高TC血症(OR=1.502)、高TG血症(OR=1.877)是远处转移的独立危险因素. 远处转移组中化疗有效组( PR+SD) ,TC、TG及LDL-C水平有降低趋势,HDL-C水平有升高趋势,疗效PR组TG水平降低有统计学意义. 结论 高脂血症与激素受体阴性乳腺癌远处转移相关,有效的抗肿瘤治疗可降低血脂水平. 动态监测血脂水平可作为激素受体阴性乳腺癌远处转移及疗效评价的辅助参考指标.
目的 測定激素受體陰性乳腺癌患者的血脂水平,探討血脂異常與遠處轉移的關繫,及化療後血脂水平變化與近期療效的關繫. 方法 收集154例激素受體陰性乳腺癌患者的臨床病理資料和空腹血脂水平,遠處轉移組患者化療2週期後第14天再次測定血脂水平. χ2 檢驗分析臨床病理特徵及基線血脂水平與遠處轉移的關繫,Logistic迴歸分析遠處轉移的獨立危險因素,配對t檢驗分析遠處轉移組患者化療後血脂各指標變化與療效關繫. 結果 乳腺癌遠處轉移與腫塊大小、區域淋巴結轉移、組織學分級、高TC、高TG及高LDL-C血癥有關(P<0.05). Logistic迴歸分析顯示,腫塊大小(OR=1.563)、區域淋巴結轉移(OR=1.983)、高TC血癥(OR=1.502)、高TG血癥(OR=1.877)是遠處轉移的獨立危險因素. 遠處轉移組中化療有效組( PR+SD) ,TC、TG及LDL-C水平有降低趨勢,HDL-C水平有升高趨勢,療效PR組TG水平降低有統計學意義. 結論 高脂血癥與激素受體陰性乳腺癌遠處轉移相關,有效的抗腫瘤治療可降低血脂水平. 動態鑑測血脂水平可作為激素受體陰性乳腺癌遠處轉移及療效評價的輔助參攷指標.
목적 측정격소수체음성유선암환자적혈지수평,탐토혈지이상여원처전이적관계,급화료후혈지수평변화여근기료효적관계. 방법 수집154례격소수체음성유선암환자적림상병리자료화공복혈지수평,원처전이조환자화료2주기후제14천재차측정혈지수평. χ2 검험분석림상병리특정급기선혈지수평여원처전이적관계,Logistic회귀분석원처전이적독립위험인소,배대t검험분석원처전이조환자화료후혈지각지표변화여료효관계. 결과 유선암원처전이여종괴대소、구역림파결전이、조직학분급、고TC、고TG급고LDL-C혈증유관(P<0.05). Logistic회귀분석현시,종괴대소(OR=1.563)、구역림파결전이(OR=1.983)、고TC혈증(OR=1.502)、고TG혈증(OR=1.877)시원처전이적독립위험인소. 원처전이조중화료유효조( PR+SD) ,TC、TG급LDL-C수평유강저추세,HDL-C수평유승고추세,료효PR조TG수평강저유통계학의의. 결론 고지혈증여격소수체음성유선암원처전이상관,유효적항종류치료가강저혈지수평. 동태감측혈지수평가작위격소수체음성유선암원처전이급료효평개적보조삼고지표.
Objective To investigate the relationship between dyslipidemia and distant metastases in pa-tients with hormone receptor( HR) negative breast cancer,and to explore the impact of blood lipid change during chemotherapy on clinical response.Methods We collected the complete clinicopathological data and fasting blood lipid in 154 patients with HR negative breast cancer.The secondary blood lipid level were measured on day14 after two cycles of chemotherapy in patients with distant metastases.Single factor chi -square test was choosen to analyze the relationship between clinicopathological characteristics,including baseline lipid level,and distant metastases,then independent risk factor for distant metastases were evaluated by logistic regression model. Data about altered blood lipid and clinical response analysis were performed using paired t-test pre-or post-chemotherapy.Results Our results from single chi-square test showed that distant metastasis from breast canc-er was significantly associated with tumor size,local lymph node metastases,grade,higher total cholesterol( TC) , higher triglycerides(TG)and higher low-density lipoprotein(LDL)(P<0.05).For distant metastases,inde-pendent risk factors were tumor size(OR=1.563),local lymph node metastases(OR=1.983),higher TC(OR=1.502),higher TG(OR=1.877).Decreased trend of TC,TG and LDL and increased trend of HDL were showed in disease control( PR+SD) group,and TG had significantly tend in objective response( PR) group.Conclusion Hyperlipidmia is significantly associated with distant metastases in patients with HR negative breast cancer,andblood lipid levels decrease with effective anti -tumor chemotherapy.Dynamic monitoring of blood lipid levelscould be a candidate surrogate biomarker for outcome prediction and distant metastases in patients with HR negativebreast cancer.
