CAJ | 학술논문

微RNA( miRNA)是一类在转录后水平通过对靶信使RNA降解或抑制翻译过程起负性调节作用的内源性单链小分子RNA。迄今，上万种miRNA已经得到成功鉴定。 miRNA广泛存在于生物体内，其序列高度保守，在生物体的多种生理和病理过程中发挥着重要的调控作用，具有十分重要的研究价值和非常广阔的应用前景。该文就miRNA的命名规则、形成过程、生物学特征、主要功能、研究策略及应用予以综述。
미RNA( miRNA)시일류재전록후수평통과대파신사RNA강해혹억제번역과정기부성조절작용적내원성단련소분자RNA。흘금，상만충miRNA이경득도성공감정。 miRNA엄범존재우생물체내，기서렬고도보수，재생물체적다충생리화병리과정중발휘착중요적조공작용，구유십분중요적연구개치화비상엄활적응용전경。해문취miRNA적명명규칙、형성과정、생물학특정、주요공능、연구책략급응용여이종술。
MicroRNAs( miRNAs) are a class of small non-coding endogenous RNA molecules and they are believed to regulate the gene expression negatively at the post-transcriptional level by degrading or repressing target messenger RNAs( mRNAs) . In recent years,tens of thousands of miRNAs have been identi-fied successfully. Generally,miRNAs are highly conserved in organisms,which play critical roles in a variety of physiological and pathological processes,with bright research prospects and enormous application value. Here is to make a review of the present research progresses of the nomination,formation,biocharacteristics, main function,research strategies and applications of miRNAs.