CAJ | 학술논문

线粒体是真核细胞中制造能量的机构，其在维持细胞内钙稳态、信号转导以及细胞凋亡中发挥重要作用。当线粒体产生大量活性氧类而无法消除时，可引起线粒体功能障碍，导致细胞死亡和组织损害。线粒体活性氧类在动脉硬化、高血压、心肌缺血/再灌注、心力衰竭等心血管疾病的发生、发展中起重要作用，深入了解线粒体活性氧类与线粒体功能障碍的关系，对更好地理解心血管疾病的发生机制有重要意义。
선립체시진핵세포중제조능량적궤구，기재유지세포내개은태、신호전도이급세포조망중발휘중요작용。당선립체산생대량활성양류이무법소제시，가인기선립체공능장애，도치세포사망화조직손해。선립체활성양류재동맥경화、고혈압、심기결혈/재관주、심력쇠갈등심혈관질병적발생、발전중기중요작용，심입료해선립체활성양류여선립체공능장애적관계，대경호지리해심혈관질병적발생궤제유중요의의。
Mitochondria is an important organelle of energy generation in eukaryocytes and plays a pivotal role in cell calcium homeostasis,signal transduction and apoptotic regulation. When a large number of mitochondrial reactive oxygen species cannot be eliminated,it can cause mitochondrial dysfunction,leading to cell death and tissue damage. Numerous studies show that mitochondrial reactive oxygen species play an important role in the pathogenesis of atherosclerosis,hypertension,myocardial ischemia and reperfusion,heart failure etc. Understanding the relationship between mitochondrial reactive oxygen species and mitochondrial dysfunction is of great significance for th better understanding of the mechanisms of cardiovascular disease.