CAJ | 학술논문

微RNAs( miRNAs)目前被认为是缺氧的新型调控基因,它能调节基因表达并且参与许多正常细胞和肿瘤细胞的生理过程。研究表明,缺氧诱导因1(HIF1)能调控一系列miRNAs,同时一些miRNAs又以HIF1为靶基因。 miRNAs与HIF1相互作用与肿瘤相关,如血管生成、代谢、细胞凋亡、细胞周期调节、增殖转移和抗癌疗法。近年来研究表明,缺氧能调节miRNAs的表达,而miRNAs也参与肿瘤靶基因的调控,进而miRNAs在分子水平影响人类肿瘤细胞的代谢、凋亡、转移和治疗等。
미RNAs( miRNAs)목전피인위시결양적신형조공기인,타능조절기인표체병차삼여허다정상세포화종류세포적생리과정。연구표명,결양유도인1(HIF1)능조공일계렬miRNAs,동시일사miRNAs우이HIF1위파기인。 miRNAs여HIF1상호작용여종류상관,여혈관생성、대사、세포조망、세포주기조절、증식전이화항암요법。근년래연구표명,결양능조절miRNAs적표체,이miRNAs야삼여종류파기인적조공,진이miRNAs재분자수평영향인류종류세포적대사、조망、전이화치료등。
MiRNAs are recognized as a new class of master regulators under hypoxia that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1(HIF1) regulates a panel of miRNAs,whereas some of miRNAs target HIF1. The interaction between miRNAs and HIF1 can account for many vital events relevant to tumorigenesis,such as angiogenesis,metabolism,apoptosis,cell cycle regulation,proliferation,metastasis,and resistance to antican-cer therapy. Recently, a few reports revealed that hypoxia regulates the expression of miRNAs, which are involved in tumor target gene regulation,thus influence a wide variety of human tumors on molecular level, such as metabolism,apoptosis,metastasis and treatment.