CAJ | 학술논문

目的：检测肝硬化患者 CD64、血清降钙素原（PCT ）水平，探讨 CD64、血清 PCT 检测对自发性细菌性腹膜炎（SBP）的诊断价值。方法将肝硬化患者分为 SBP 组（45例）、腹水非 SBP 组（93例）及对照组3组（50例），应用流式细胞术测定 CD64；电化学发光免疫法测定 PCT 。分别采集 SBP 组患者在入院后24 h 内、抗菌药物使用前及抗菌药物有效治疗7 d 空腹上肢静脉血，测定患者体内 CD64、PCT 水平，同时行血常规、肝功能、肾功能、凝血功能检查。腹水非 SBP 组及对照组一次性采血测定以上指标。结果 SBP 组 CD64、血清 PCT 水平较腹水非 SBP 组和对照组明显升高（P ＜0．01）。 ROC 曲线分析结果显示 CD64和PCT 的敏感性和特异性分别为95．5％、93．8％和96．1％、85．2％。结论 CD64、PCT 可作为肝硬化 SBP 早期诊断、疗效判定的重要指标。
목적：검측간경화환자 CD64、혈청강개소원（PCT ）수평，탐토 CD64、혈청 PCT 검측대자발성세균성복막염（SBP）적진단개치。방법장간경화환자분위 SBP 조（45례）、복수비 SBP 조（93례）급대조조3조（50례），응용류식세포술측정 CD64；전화학발광면역법측정 PCT 。분별채집 SBP 조환자재입원후24 h 내、항균약물사용전급항균약물유효치료7 d 공복상지정맥혈，측정환자체내 CD64、PCT 수평，동시행혈상규、간공능、신공능、응혈공능검사。복수비 SBP 조급대조조일차성채혈측정이상지표。결과 SBP 조 CD64、혈청 PCT 수평교복수비 SBP 조화대조조명현승고（P ＜0．01）。 ROC 곡선분석결과현시 CD64화PCT 적민감성화특이성분별위95．5％、93．8％화96．1％、85．2％。결론 CD64、PCT 가작위간경화 SBP 조기진단、료효판정적중요지표。
Objective To detect the level of CD64 and serum procalcitonin (PCT ) and investigate the diagnosis value of CD64 and serum PCT in cirrhosis patients with spontaneous bacterial peritonitis (SBP) .Methods Participants were categorized in‐to three groups including liver cirrhosis with SBP(45 patients) ,liver cirrhosis without SBP(93 patients) and health personnel(50 persons) .CD64 was detected by flow cytometry and serum PCT was measured by electroc hemiluminescence immunoassay .The li‐mosis vein blood samples were obtained from the patients with SBP at the time of 24 h after admission ,before antibacterial drugs use and 7 days after the effective treatment of antibacterial drugs .The CD64 and serum PCT were detected with the limosis vein blood samples .At the same time ,the complete blood count ,liver ,kidney and blood coagulate functions were tested .The participants in other two groups were detected the CD64 ,serum PCT ,complete blood count ,liver ,kidney and blood coagulate functions at the same time .Results The level of CD64 and serum PCT in cirrhosis patients with SBP were significantly higher than those in liver cirrhosis without SBP and normal controls (P< 0 .01) .ROC curve analysis showed that the sensitivity and specificity of CD64 and serum PCT were 95 .5% ,93 .8% and 96 .1% ,85 .2% respectively .Conclusion CD64 and serum PCT can be determined as the im‐portant indicator in early diagnosis and efficacy criterion .