CAJ | 학술논문

宫颈癌是病死率较高的妇科肿瘤之一，严重危害女性健康，因其有较长的癌前病变期，合理筛查便成为控制肿瘤发生、发展的关键。研究表明，宫颈细胞由非典型性发育异常向宫颈癌转变的过程中几乎都伴有人类染色体端粒酶( hTERC)基因的扩增，该基因扩增可阻止细胞凋亡，导致肿瘤发生。目前，利用荧光原位杂交技术( FISH)进行hTERC基因扩增检测已被用于宫颈病变的筛查。该文就hTERC基因检测对宫颈癌的诊断价值及FISH的检测优势予以综述。
궁경암시병사솔교고적부과종류지일，엄중위해녀성건강，인기유교장적암전병변기，합리사사편성위공제종류발생、발전적관건。연구표명，궁경세포유비전형성발육이상향궁경암전변적과정중궤호도반유인류염색체단립매( hTERC)기인적확증，해기인확증가조지세포조망，도치종류발생。목전，이용형광원위잡교기술( FISH)진행hTERC기인확증검측이피용우궁경병변적사사。해문취hTERC기인검측대궁경암적진단개치급FISH적검측우세여이종술。
Cervical cancer is one of the gynecological tumors,the fatality of which is high causing serious damage to women′s health. Reasonable screening has become the key to control the development of the tumor because of its longer precancerous period. Studies have showed almost all process from atypical dysplasia to cervical cancer is accompanied by amplification of human telomerase RNA component gene( hTERC gene) , which can prevent apoptosis and lead to tumorigenesis. At present,detecting the amplification of hTERC gene by fluorescence in situ hybridization( FISH) has been used in screening of cervical lesions. Here is to make a review about its progress and advantages.