CAJ | 학술논문

以抗癌药物盐酸阿霉素为模型，交联透明质酸为载体，通过溶胀作用吸附药物分子，再冷冻干燥、碾压成形，制备了一系列具有不同载药量和一定缓释效果的载药交联透明质酸膜。通过SEM观测其微结构，利用紫外分光光度法检测其药物体外释放行为，并研究不同释放时间、载药量和透明质酸酶对药物释放行为的影响。结果表明，12h内药物释放较快，随后释放平缓，药物累积释放速度与载药量呈反比；加入透明质酸酶后，由于交联透明质酸的不断降解，药物累积释放速度比无透明质酸酶时快。
이항암약물염산아매소위모형，교련투명질산위재체，통과용창작용흡부약물분자，재냉동간조、년압성형，제비료일계렬구유불동재약량화일정완석효과적재약교련투명질산막。통과SEM관측기미결구，이용자외분광광도법검측기약물체외석방행위，병연구불동석방시간、재약량화투명질산매대약물석방행위적영향。결과표명，12h내약물석방교쾌，수후석방평완，약물루적석방속도여재약량정반비；가입투명질산매후，유우교련투명질산적불단강해，약물루적석방속도비무투명질산매시쾌。
Using anti-cancer drug doxorubicin hydrochloride and cross-linking hyaluronic acid as a model and a carrier respectively,a series of cross linking hyaluronic acid films bearing different loadings of doxorubicin hydrochloride and sustained-release activities have been prepared by swelling in the sorption of drug molecules,freeze-drying,and crushing. Their microstructures and drug release behaviorsin vitro were investigated by SEM and ultraviolet spectrophotometer,respectively. The effects of different time,drug loadings and hyaluronidase,on drug release behavior were studied,and the results showed that the drug releases fast within 12 h,then gets slow,the drug cumulative release speed is inversely proportional to drug loading,and the drug cumulative release speed in the presence of hyaluronidase is faster than that without hyaluronidase because of the continuously degradation of cross-linked hyaluronic acid.