重庆医学
重慶醫學
중경의학
Chongqing Medicine
2015年
30期
4213-4215
,共3页
胰腺肿瘤%结缔组织生长因子%PCNP
胰腺腫瘤%結締組織生長因子%PCNP
이선종류%결체조직생장인자%PCNP
pancreatic neoplasms%connective tissue growth factor%PEST containing nuclear protein
目的：探讨结缔组织生长因子（CTGF）、PCNP在胰腺癌组织中的表达水平及意义。方法采用免疫组织化学法与蛋白质免疫印迹法检测39例胰腺癌及癌旁组织中CTGF和PCNP的表达情况，分析其与临床病理因素的关系。结果 CTGF、PCNP在胰腺癌中的阳性表达率均显著高于癌旁组织和正常胰腺组织，差异有统计学意义（χ2＝60．41、51．46，均 P＜0．01）；CT‐GF、PCNP的阳性表达率分别与TNM分期、淋巴结转移明显相关（P＜0．05）。结论 CTGF、PCNP在胰腺癌组织中表达明显上升，且两者的表达水平与肿瘤的分期、淋巴结转移状况有着明显的相关性。
目的：探討結締組織生長因子（CTGF）、PCNP在胰腺癌組織中的錶達水平及意義。方法採用免疫組織化學法與蛋白質免疫印跡法檢測39例胰腺癌及癌徬組織中CTGF和PCNP的錶達情況，分析其與臨床病理因素的關繫。結果 CTGF、PCNP在胰腺癌中的暘性錶達率均顯著高于癌徬組織和正常胰腺組織，差異有統計學意義（χ2＝60．41、51．46，均 P＜0．01）；CT‐GF、PCNP的暘性錶達率分彆與TNM分期、淋巴結轉移明顯相關（P＜0．05）。結論 CTGF、PCNP在胰腺癌組織中錶達明顯上升，且兩者的錶達水平與腫瘤的分期、淋巴結轉移狀況有著明顯的相關性。
목적：탐토결체조직생장인자（CTGF）、PCNP재이선암조직중적표체수평급의의。방법채용면역조직화학법여단백질면역인적법검측39례이선암급암방조직중CTGF화PCNP적표체정황，분석기여림상병리인소적관계。결과 CTGF、PCNP재이선암중적양성표체솔균현저고우암방조직화정상이선조직，차이유통계학의의（χ2＝60．41、51．46，균 P＜0．01）；CT‐GF、PCNP적양성표체솔분별여TNM분기、림파결전이명현상관（P＜0．05）。결론 CTGF、PCNP재이선암조직중표체명현상승，차량자적표체수평여종류적분기、림파결전이상황유착명현적상관성。
Objective To study the expression of connective tissue growth factor(CTGF) and PEST containing nuclear pro‐tein(PCNP) and their significance in pancreatic cancer .Methods The expressions of CTGF and PCNP proteins were tested by im‐munohistochemistry and Immunofluorescence in 39 cases of pancreatic carcinomas and adjacent paracancerous tissues .Results The positive rate of CTGF and PCNP in pancreatic carcinomas was significantly higher than adjacent paracancerous tissues(χ2 =60 .41 , 51 .46 ,all P<0 .01) .The differences of the expression of CTGF and PCNP in pancreatic carcinoma of tumor differentiation ,TNM stage and lymph node metastasis was significant (P< 0 .05) .Conclusion The expression of CTGF and PCNP in the pancreatic cancer was obviously increased ,and the level of CTGF ,PCNP had remarkable connection with the stages of tumor and the condition of lymph node metastasis .
