CAJ | 학술논문

目的：探讨亚临床甲状腺功能减退症（SCH）患者血脂、血尿酸（UA）、内脂素（visfatin）、同型半胱氨酸（HCY）、超敏C反应蛋白（hs‐CRP）的变化及意义。方法将100例 SCH 患者根据促甲状腺激素（TSH ）水平分为观察 A 组（5 mIU／L ≤TSH＜10 mIU／L ，60例）和观察B组（TSH≥10 mIU／L ，40例）；对照组为健康体检者（100例）。检测患者血清 TSH、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL‐C）、低密度脂蛋白胆固醇（LDL‐C）、UA、HCY、hs‐CRP、visfatin水平并进行分析。结果观察A组患者血TG、visfatin水平与对照组比较，差异均有统计学意义（P＜0．05）；观察B组患者血 TG、visfatin、LDL‐C、UA、HCY、hs‐CRP水平均较与对照组明显增高（P＜0．05），并以 TG、visfatin升高最为显著（P＜0．01）。但A、B两组患者血HDL‐C水平与对照组比较，差异均无统计学意义（P＞0．05）。结论 SCH患者脂质代谢紊乱和高尿酸血症可能是促发动脉粥样硬化的重要危险因素；HCY、hs‐CRP、visfatin可作为SCH患者动脉粥样硬化程度的预测指标。
목적：탐토아림상갑상선공능감퇴증（SCH）환자혈지、혈뇨산（UA）、내지소（visfatin）、동형반광안산（HCY）、초민C반응단백（hs‐CRP）적변화급의의。방법장100례 SCH 환자근거촉갑상선격소（TSH ）수평분위관찰 A 조（5 mIU／L ≤TSH＜10 mIU／L ，60례）화관찰B조（TSH≥10 mIU／L ，40례）；대조조위건강체검자（100례）。검측환자혈청 TSH、총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL‐C）、저밀도지단백담고순（LDL‐C）、UA、HCY、hs‐CRP、visfatin수평병진행분석。결과관찰A조환자혈TG、visfatin수평여대조조비교，차이균유통계학의의（P＜0．05）；관찰B조환자혈 TG、visfatin、LDL‐C、UA、HCY、hs‐CRP수평균교여대조조명현증고（P＜0．05），병이 TG、visfatin승고최위현저（P＜0．01）。단A、B량조환자혈HDL‐C수평여대조조비교，차이균무통계학의의（P＞0．05）。결론 SCH환자지질대사문란화고뇨산혈증가능시촉발동맥죽양경화적중요위험인소；HCY、hs‐CRP、visfatin가작위SCH환자동맥죽양경화정도적예측지표。
Objective To investigate the changes and significance of risk factors (blood lipid ,UA ,visfatin ,HCY and hs CRP) for cardiovascular diseases in patients with subclinical hypothyroidism(SCH) .Methods One hundred patients with SCH were divided into observation group A (5 mIU/L≤TSH<10 mIU/L ,n=60) and observation group B (TSH≥10 mIU/L ,n=40) in accordance with thyroid stimulating hormone (TSH ) level .The control group included one hundred healthy individuals .We measured the factors of cardiovascular diseases such as TSH ,total cholesterol (TC) ,triglyceride (TG) ,high density lipoprotein cholesterol (HDL‐C) ,low density lipoprotein cholesterol (LDL‐C) ,serum uric acid (UA) ,visfatin ,homocysteine (HCY) and high sensitive C‐reactive protein (hs‐CRP) and visfatin level .Results The levels of TG and visfatin of observation groups were signifi‐cantly higher than control group (P<0 .05) .In group B ,levels of TG ,visfatin ,LDL‐C ,UA ,HCY and hs‐CRP were much more sig‐nificantly higher than control group(P<0 .05) ,and TG and visfatin had the most significant increase (P<0 .01) ,and there were no significant different in HDL‐C in group A and B(P>0 .05) .Conclusion In Subclinical hypothyroidism patients ,lipid disorders and hyperuricemia are the risk factors of thyroid nodules and coronary heart disease .HCY ,hs‐CRP and visfatin should be used as the indicators to evaluate the cardiovascular risk .