CAJ | 학술논문

目的：系统评价羟考酮／对乙酰氨基酚术后急性疼痛治疗的有效性和安全性。方法计算机检索 PubM ed、EM‐base、MEDLINE（Ovid）、Cochrane图书馆、CNKI、万方等电子数据库，查找羟考酮／对乙酰氨基酚术后疼痛治疗的随机对照试验（RCT ），检索时间均从建库至2014年9月。对符合纳入标准的RCT ，由两位评价员按 Cochrane系统评价的方法，独立进行资料提取、质量评价并交叉核对后，采用RevMan 5．2软件进行Meta分析。结果本系统评价纳入19个研究，合计2213例患者。结果显示：羟考酮／对乙酰氨基酚组在疼痛缓解有效率上明显优于安慰剂组与单用同剂量羟考酮组（P＜0．01），而与单用高剂量羟考酮组及单用对乙酰氨基酚组在疼痛缓解有效率上差异无统计学意义（P＞0．05）。不良反应方面发生率，组合药物与单用羟考酮组相似，多于安慰剂组及单用对乙酰氨基酚组，但程度一般为轻度到中度，无因严重不良反应而退出治疗的报道。结论目前研究表明羟考酮／对乙酰氨基酚在缓解术后急性疼痛方面效果良好且安全性高。
목적：계통평개간고동／대을선안기분술후급성동통치료적유효성화안전성。방법계산궤검색 PubM ed、EM‐base、MEDLINE（Ovid）、Cochrane도서관、CNKI、만방등전자수거고，사조간고동／대을선안기분술후동통치료적수궤대조시험（RCT ），검색시간균종건고지2014년9월。대부합납입표준적RCT ，유량위평개원안 Cochrane계통평개적방법，독립진행자료제취、질량평개병교차핵대후，채용RevMan 5．2연건진행Meta분석。결과본계통평개납입19개연구，합계2213례환자。결과현시：간고동／대을선안기분조재동통완해유효솔상명현우우안위제조여단용동제량간고동조（P＜0．01），이여단용고제량간고동조급단용대을선안기분조재동통완해유효솔상차이무통계학의의（P＞0．05）。불량반응방면발생솔，조합약물여단용간고동조상사，다우안위제조급단용대을선안기분조，단정도일반위경도도중도，무인엄중불량반응이퇴출치료적보도。결론목전연구표명간고동／대을선안기분재완해술후급성동통방면효과량호차안전성고。
Objective To assess the effectivity and safety of oxycodone plus acetaminophen for postoperative acute pain re‐lief .Methods Randomized controlled trials (RCT ) on combination of oxycodone plus acetaminophen treating postoperative pain re‐lief were searched from the following data‐bases as PubMed ,EMbase ,MEDLINE(Ovid) ,the Cochrane Library ,CNKI and WAN‐FANG from the date of their establishment to September 2014 .The data of RCT meeting the inclusive criteria were extracted ac‐cording to Cochrane methods by two reviewers independently ,and after the quality was evaluated and cross checked ,meta analyses were conducted using RevMan 5 .2 sotware .Results A total of 18 studies involving 2 213 patients were included .The results of Meta‐analyses showed that compared with placebo group or the equal dosage oxycodone alone group ,the combinations of oxycodone plus acetaminophen were more effective in postoperative pain relief (P<0 .01) .However ,there are no significant difference in the effective between the combinations of oxycodone plus acetaminophen and the higher dosage oxycodone alone group or the acetamin‐ophen alone group for postoperative pain relief (P>0 .05) .Adverse events occurred more frequently with combination therapy than placebo or acetaminophen alone group ,but were generally described as mild to moderate in severity and rarely led to withdrawal . There are no significant difference in the adverse events between the combination of oxycodone plus acetaminophen and the oxyc‐odone alone group .Conclusion The present study showed that combination of oxycodone plus acetaminophen is effective and high safe in postoperative acute pain relief .