心血管病防治知识（下半月）
心血管病防治知識（下半月）
심혈관병방치지식（하반월）
Xinxueguanbing Fangzhi Zhishi
2015年
10期
34-36
,共3页
氯吡格雷%阿司匹林%不稳定型心绞痛
氯吡格雷%阿司匹林%不穩定型心絞痛
록필격뢰%아사필림%불은정형심교통
Clopidogrel%Aspirin%Unstable angina
目的：探究氯吡格雷联合阿司匹林在不稳定型心绞痛治疗中的效果及其安全性。方法选取我院于2014年2月到2015年2月收治的56例不稳定型心绞痛患者，将他们随机分为治疗组与对照组，每组各28例。在常规治疗的基础上，治疗组患者使用氯吡格雷药物联合阿司匹林进行治疗，对照组的患者单使用阿司匹林药物进行治疗，治疗时间为4周，治疗结束后对两组患者的治疗效果以及不良反应的发生情况。结果治疗组患者的总体治疗有效率为92.86%，对照组患者的总体治疗有效率为71.43%，治疗组明显高于对照组，P﹤0.05。另外，治疗组患者治疗前的全血粘度是（5.22±0.58）mpa/s，治疗后为（4.67±0.66）mpa/s，P﹤0.05。而对照组治疗前后的全血粘度为（5.33±0.70）mpa/s，比（5.17±0.61）mpa/s，P﹥0.05。两组患者不良反应，无差异P﹥0.05。结论不稳定型心绞痛患者使用氯吡格雷联合阿司匹林来治疗能够有效地提高治疗效果，不增加不良反应的发生，值得推广与应用。
目的：探究氯吡格雷聯閤阿司匹林在不穩定型心絞痛治療中的效果及其安全性。方法選取我院于2014年2月到2015年2月收治的56例不穩定型心絞痛患者，將他們隨機分為治療組與對照組，每組各28例。在常規治療的基礎上，治療組患者使用氯吡格雷藥物聯閤阿司匹林進行治療，對照組的患者單使用阿司匹林藥物進行治療，治療時間為4週，治療結束後對兩組患者的治療效果以及不良反應的髮生情況。結果治療組患者的總體治療有效率為92.86%，對照組患者的總體治療有效率為71.43%，治療組明顯高于對照組，P﹤0.05。另外，治療組患者治療前的全血粘度是（5.22±0.58）mpa/s，治療後為（4.67±0.66）mpa/s，P﹤0.05。而對照組治療前後的全血粘度為（5.33±0.70）mpa/s，比（5.17±0.61）mpa/s，P﹥0.05。兩組患者不良反應，無差異P﹥0.05。結論不穩定型心絞痛患者使用氯吡格雷聯閤阿司匹林來治療能夠有效地提高治療效果，不增加不良反應的髮生，值得推廣與應用。
목적：탐구록필격뢰연합아사필림재불은정형심교통치료중적효과급기안전성。방법선취아원우2014년2월도2015년2월수치적56례불은정형심교통환자，장타문수궤분위치료조여대조조，매조각28례。재상규치료적기출상，치료조환자사용록필격뢰약물연합아사필림진행치료，대조조적환자단사용아사필림약물진행치료，치료시간위4주，치료결속후대량조환자적치료효과이급불량반응적발생정황。결과치료조환자적총체치료유효솔위92.86%，대조조환자적총체치료유효솔위71.43%，치료조명현고우대조조，P﹤0.05。령외，치료조환자치료전적전혈점도시（5.22±0.58）mpa/s，치료후위（4.67±0.66）mpa/s，P﹤0.05。이대조조치료전후적전혈점도위（5.33±0.70）mpa/s，비（5.17±0.61）mpa/s，P﹥0.05。량조환자불량반응，무차이P﹥0.05。결론불은정형심교통환자사용록필격뢰연합아사필림래치료능구유효지제고치료효과，불증가불량반응적발생，치득추엄여응용。
Objective To investigate the efficacy and safety of clopidogrel plus aspirin in the treatment of unstable angina. Methods Fifty-six patients with unstable angina who were admitted to our hospital from February 2014 to February 2015 were randomly and equally divided into treatment group and control group. On the basis of conventional therapy, patients in the treatment group were given clopidogrel plus aspirin for four weeks, while patients in the control group were given aspirin alone for four weeks. The treatment outcomes and adverse reactions were compared between the two groups after treatment. Results The overall response rate was significantly higher in the treatment group than in the control group (92.86%vs 71.43%, P﹤0.05). Moreover, the whole blood viscosity in the treatment group was significantly reduced after treatment (5.22±0.58 vs 4.67±0.66 mPa·s, P﹤0.05), while there was no significant change in the whole blood viscosity in the control group after treatment (5.33±0.70 vs 5.17±0.61 mPa·s, P﹥0.05). There were no significant differences in adverse reactions between the two groups (P﹥0.05). Conclusion Clopidogrel plus aspirin can effectively improve treatment outcomes and control the incidence of adverse reactions in patients with unstable angina, which holds promise for wide application.
