CAJ | 학술논문

目的：探讨孕妇妊娠期甲状腺激素水平变化及与抗甲状腺过氧化物酶抗体（TPOAb）的相关性。方法选取2012年11月至2014年5月来宁夏回族自治区石嘴山市妇幼保健院进行检查的150例孕妇作为研究对象，根据TPOAb对孕妇进行分组。比较两组孕妇的临床资料、血清甲状腺激素水平、妊娠结局和新生儿并发症的发生率。结果150例患者中，TPOAb阳性者44例，阴性106例。两组孕妇的年龄、孕周和BMI差异无统计学意义（P＞0．05）。妊娠早中期和晚期，两组孕妇的甲状腺激素水平差异有统计学意义（P＜0．05）；观察组（TPOAb阳性）孕妇妊娠前后的甲状腺激素水平差异有统计学意义（P＜0．05）。两组孕妇的不良妊娠结局和新生儿并发症的发生率差异有统计学意义（P＜0．05）。结论妊娠期的TPOAb对妊娠期亚临床甲状腺功能减退的诊断和妊娠结局的判断具有一定的意义。
목적：탐토잉부임신기갑상선격소수평변화급여항갑상선과양화물매항체（TPOAb）적상관성。방법선취2012년11월지2014년5월래저하회족자치구석취산시부유보건원진행검사적150례잉부작위연구대상，근거TPOAb대잉부진행분조。비교량조잉부적림상자료、혈청갑상선격소수평、임신결국화신생인병발증적발생솔。결과150례환자중，TPOAb양성자44례，음성106례。량조잉부적년령、잉주화BMI차이무통계학의의（P＞0．05）。임신조중기화만기，량조잉부적갑상선격소수평차이유통계학의의（P＜0．05）；관찰조（TPOAb양성）잉부임신전후적갑상선격소수평차이유통계학의의（P＜0．05）。량조잉부적불량임신결국화신생인병발증적발생솔차이유통계학의의（P＜0．05）。결론임신기적TPOAb대임신기아림상갑상선공능감퇴적진단화임신결국적판단구유일정적의의。
Objective To study the relevance between the level of thyroid hormone and anti‐thyroid peroxidase antibody (TPOAb) during gestation period .Methods From November 2011 to May 2014 ,150 gravidas were chosen as objectives ,and were divided into 2 groups according TPOAb .The clinical feature ,level of thyroid hormone ,pregnancy outcome ,and complication of neo‐phyte between 2 groups were compared .Results In 150 gravidas ,44 were positive in TPOAb and 106 were negative .The age ,ges‐tational weeks and BMI between two groups had no statistical difference(P>0 .05) .At the early and middle pregnancy as well as at the late pregnancy ,the level of thyroid hormone between two groups had statistical difference(P<0 .05);In study group ,the level of thyroid hormone of early and middle pregnancy and that of late pregnancy had statistical difference(P<0 .05) .The rate of unde‐sirable gestational outcome and that of neophyte complication between two groups had statistical difference(P<0 .05) .Conclusion During gestation period ,the TPOAb was significant for the diagnosis of the sub‐clinical hypothyroidism ,as well for prognosis of gravidas .