重庆医学
重慶醫學
중경의학
Chongqing Medicine
2015年
28期
3962-3965
,共4页
XRCC1%多态性 ,单核苷酸%鼻咽肿瘤%Meta 分析
XRCC1%多態性 ,單覈苷痠%鼻嚥腫瘤%Meta 分析
XRCC1%다태성 ,단핵감산%비인종류%Meta 분석
X-ray cross-complementing group 1%polymorphism,single nucleotide%nasopharyngeal neoplasms%Meta analysis
目的:系统评价 DNA 修复 X 射线损伤修复的交叉互补基因(XRCC1)Arg399Gln 基因多态性与鼻咽癌的遗传易感性。方法检索中国医学文献数据库及 PubMed 数据库,得出 Arg399Gln 基因多态性与鼻咽癌遗传易感性的病例‐对照研究。运用 Review Manager 5.0及 Stata12.0软件对各研究数据进行统计分析,并对文献发表偏倚、结果数据的可靠性进行评价。采取固定效应模型或随机效应模型,以合并 OR 值及相应95% CI 评估 Arg399Gln 多态与鼻咽癌的遗传易感性。结果399Gln 等位基因与399Arg 相比,合并 OR 值及95% CI 分别为1.14(1.04~1.26),经异质性检验,I2=32%,PHet =0.18。隐性模型及共显性模型下合并 OR 值及95% CI 分别为1.30(1.04~1.63)、1.37(1.09~1.72),经异质性检验两种模型下均不存在明显异质性,统计分析 I2和相应 PHet分别为(I2=0,PHet =1.00);(I2=0,PHet =0.96)。结论 XRCC1基因 Arg399Gln 多态性与鼻咽癌的遗传易感性密切相关,399Gln 等位基因可能是亚洲人群鼻咽癌发病的危险遗传因素。
目的:繫統評價 DNA 脩複 X 射線損傷脩複的交扠互補基因(XRCC1)Arg399Gln 基因多態性與鼻嚥癌的遺傳易感性。方法檢索中國醫學文獻數據庫及 PubMed 數據庫,得齣 Arg399Gln 基因多態性與鼻嚥癌遺傳易感性的病例‐對照研究。運用 Review Manager 5.0及 Stata12.0軟件對各研究數據進行統計分析,併對文獻髮錶偏倚、結果數據的可靠性進行評價。採取固定效應模型或隨機效應模型,以閤併 OR 值及相應95% CI 評估 Arg399Gln 多態與鼻嚥癌的遺傳易感性。結果399Gln 等位基因與399Arg 相比,閤併 OR 值及95% CI 分彆為1.14(1.04~1.26),經異質性檢驗,I2=32%,PHet =0.18。隱性模型及共顯性模型下閤併 OR 值及95% CI 分彆為1.30(1.04~1.63)、1.37(1.09~1.72),經異質性檢驗兩種模型下均不存在明顯異質性,統計分析 I2和相應 PHet分彆為(I2=0,PHet =1.00);(I2=0,PHet =0.96)。結論 XRCC1基因 Arg399Gln 多態性與鼻嚥癌的遺傳易感性密切相關,399Gln 等位基因可能是亞洲人群鼻嚥癌髮病的危險遺傳因素。
목적:계통평개 DNA 수복 X 사선손상수복적교차호보기인(XRCC1)Arg399Gln 기인다태성여비인암적유전역감성。방법검색중국의학문헌수거고급 PubMed 수거고,득출 Arg399Gln 기인다태성여비인암유전역감성적병례‐대조연구。운용 Review Manager 5.0급 Stata12.0연건대각연구수거진행통계분석,병대문헌발표편의、결과수거적가고성진행평개。채취고정효응모형혹수궤효응모형,이합병 OR 치급상응95% CI 평고 Arg399Gln 다태여비인암적유전역감성。결과399Gln 등위기인여399Arg 상비,합병 OR 치급95% CI 분별위1.14(1.04~1.26),경이질성검험,I2=32%,PHet =0.18。은성모형급공현성모형하합병 OR 치급95% CI 분별위1.30(1.04~1.63)、1.37(1.09~1.72),경이질성검험량충모형하균불존재명현이질성,통계분석 I2화상응 PHet분별위(I2=0,PHet =1.00);(I2=0,PHet =0.96)。결론 XRCC1기인 Arg399Gln 다태성여비인암적유전역감성밀절상관,399Gln 등위기인가능시아주인군비인암발병적위험유전인소。
Objective To evaluate the association between SNP 399 in X‐ray cross‐complementing group 1 (XRCC1) and na‐sopharyngeal carcinoma susceptibility .Methods The case‐control studies on the association between SNP 399 in XRCC1 (X‐ray cross‐complementing group 1) and nasopharyngeal carcinoma susceptibility were collected by CBM disc and Pubmed .Various re‐search and statistical analysis were used by Stata12 .0 and Review Manager 5 .0 software .Taking the fixed effects model or random effects model to merge OR values and corresponding 95% confidence intervals to assess Arg399Gln polymorphism and genetic sus‐ceptibility to nasopharyngeal .Results Compared 399Gln with 399Arg allele ,combined OR and 95% CI were 1 .14 (1 .04 - 1 .26) respectively ,and the results of heterogeneity test was I2 = 32% ,PHet = 0 .18 .Under the recessive and co‐dominant models ,combined OR and 95% CI were 1 .30(1 .04 - 1 .63) and 1 .37(1 .09 - 1 .72) respectively ,and with no significant heterogeneity was observed (I2 = 0 ,PHet = 1 .00) and (I2 = 0 ,PHet = 0 .96) .Conclusion XRCC1 gene Arg399Gln polymorphism is closely related to the genetic susceptibility of NPC ,399Gln allele may be a risk of genetic factors in NPC incidence in asians .