CAJ | 학술논문

目的：采用 Meta 分析方法综合比较中国的年轻女性乳腺癌（≤35岁）与中老年乳腺癌（＞35岁）的临床病理特征。方法系统地收集中国年轻女性乳腺癌临床病理特征的相关研究文献，并对纳入文献进行质量评价；采用 Stata12．0软件进行数据分析，得到合并 OR 值及其95％ CI 。结果纳入合格研究文献31篇，文献质量评价多在6～7分，纳入文献质量较高；年轻乳腺癌和中老年乳腺癌患者之间有统计学差异的临床病理特征为误诊率、临床0～Ⅱ期或Ⅰ～Ⅱ期，病理类型为浸润性癌、组织学Ⅲ级和淋巴结转移阳性，OR 值分别为6．42（95％ CI ：4．22～9．79）、0．61（95％ CI ：0．50～0．74）、2．25（95％ CI ：1．69～2．99）、1．73（95％ CI ：1．23～2．43）、1．80（95％ CI ：1．23～2．43）。结论与中老年乳腺癌患者相比，年轻乳腺癌具有误诊率高、临床分期晚、浸润性癌比例高、组织学分化差及易发生淋巴转移的临床病理特点，提示对年轻乳腺癌的筛查和治疗可能应采用不同的原则和措施。
목적：채용 Meta 분석방법종합비교중국적년경녀성유선암（≤35세）여중노년유선암（＞35세）적림상병리특정。방법계통지수집중국년경녀성유선암림상병리특정적상관연구문헌，병대납입문헌진행질량평개；채용 Stata12．0연건진행수거분석，득도합병 OR 치급기95％ CI 。결과납입합격연구문헌31편，문헌질량평개다재6～7분，납입문헌질량교고；년경유선암화중노년유선암환자지간유통계학차이적림상병리특정위오진솔、림상0～Ⅱ기혹Ⅰ～Ⅱ기，병리류형위침윤성암、조직학Ⅲ급화림파결전이양성，OR 치분별위6．42（95％ CI ：4．22～9．79）、0．61（95％ CI ：0．50～0．74）、2．25（95％ CI ：1．69～2．99）、1．73（95％ CI ：1．23～2．43）、1．80（95％ CI ：1．23～2．43）。결론여중노년유선암환자상비，년경유선암구유오진솔고、림상분기만、침윤성암비례고、조직학분화차급역발생림파전이적림상병리특점，제시대년경유선암적사사화치료가능응채용불동적원칙화조시。
Objective To compare the clinical and pathological features of Chinese young breast cancer(age ≤ 35)with elder patients(> 35)using Meta analysis .Methods Published studies concerning clinical and pathological features of young breast cancer in China were searched systemically and assessed .Stata12 .0 software was used for data analyzing and calculating OR and its 95%CI .Results Totally 31 studies were selected for Meta analysis ,and most of them were classified as 6 - 7 scores ,which showed the quality of articles was high .The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as fol‐lows 6 .42(95% CI :4 .22 - 9 .79) ,0 .61(95% CI :0 .50 - 0 .74)when clinical staging of 0 - Ⅱ phase or Ⅰ - Ⅱ phase ,2 .25(95% CI :1 .69 - 2 .99)when histological type of Invasive carcinoma ,1 .73(95% CI :1 .23 - 2 .43)when histological grade of III grade ,1 .80 (95% CI :1 .23 - 2 .43)when positive of lymph node metastasis .Conclusion Compared with elder breast cancer ,the clinical and pathological characteristics of young breast cancer were mainly for the high misdiagnosis rate ,the late clinical stage ,the high pro‐portion invasive carcinoma ,the poor histological differentiation and the lymph node metastasising easily ,the hint of young breast cancer screening and treatment may be different principles and measures should be adopted .