重庆医学
重慶醫學
중경의학
Chongqing Medicine
2015年
29期
4112-4115
,共4页
薛晶%赵杨%张建伟%焦艳%申兴斌
薛晶%趙楊%張建偉%焦豔%申興斌
설정%조양%장건위%초염%신흥빈
结直肠腺瘤%胰岛素样生长因子结合蛋白2%胰岛素样生长因子结合蛋白6%免疫组织化学%逆转录聚合酶链反应
結直腸腺瘤%胰島素樣生長因子結閤蛋白2%胰島素樣生長因子結閤蛋白6%免疫組織化學%逆轉錄聚閤酶鏈反應
결직장선류%이도소양생장인자결합단백2%이도소양생장인자결합단백6%면역조직화학%역전록취합매련반응
colorectaldenoma%insulin-like grow th factor binding protein 2%insulin-like grow th factor binding protein 6%im-munohistochemistry%reverse transcriptase polymerase chain reaction
目的:研究胰岛素样生长因子结合蛋白(IGFBP)‐2及 IGFBP‐6在结直肠腺瘤(CRA)中的表达及临床意义。方法收集承德医学院附属医院2012年7月至2013年3月手术治疗后经病理证实为CRA 50例(CRA组)、结直肠癌(CRC )组织标本50例(CRC组),结直肠正常黏膜20例(对照组)。采用免疫组织化学法及RT‐PCR方法检测IGFBP‐2及IGFBP‐6的蛋白及mRNA的表达情况,结合临床病理资料进行统计学分析。结果 IGFBP‐2蛋白的阳性表达及mRNA的表达量在CRA组与对照组比较有升高趋势;而与CRC组比较则有降低趋势,且差异有统计学意义(P<0.05),而IGFBP‐6蛋白的阳性表达在CRA组与对照组比较有降低趋势;而与CRC组比较则有升高趋势,IGFBP‐6 mRNA表达量在CRA组与对照组比较有升高趋势;而与CRC组比较则有降低趋势,且差异有统计学意义(P<0.05),在CRA组,IGFBP‐2、IGFBP‐6的阳性表达与患者的年龄、性别、肿瘤的数量及部位差异均无统计学意义(P>0.05),但是其与增生程度差异有统计学意义(P<0.05);在CRA组,IGFBP‐2与IGFBP‐6的表达相互间呈负相关,差异有统计学意义(P<0.01)。结论 CRA在结直肠正常黏膜向CRC转化过程中的中间环节,而在其发生、发展过程中,胰岛素样生长因子家族(IGFs)与IGFS‐R轴发挥着重要且不可替代的作用,所以IGFBP‐2、IGFBP‐6有可能作为CRA诊断及预后的早期预测指标。
目的:研究胰島素樣生長因子結閤蛋白(IGFBP)‐2及 IGFBP‐6在結直腸腺瘤(CRA)中的錶達及臨床意義。方法收集承德醫學院附屬醫院2012年7月至2013年3月手術治療後經病理證實為CRA 50例(CRA組)、結直腸癌(CRC )組織標本50例(CRC組),結直腸正常黏膜20例(對照組)。採用免疫組織化學法及RT‐PCR方法檢測IGFBP‐2及IGFBP‐6的蛋白及mRNA的錶達情況,結閤臨床病理資料進行統計學分析。結果 IGFBP‐2蛋白的暘性錶達及mRNA的錶達量在CRA組與對照組比較有升高趨勢;而與CRC組比較則有降低趨勢,且差異有統計學意義(P<0.05),而IGFBP‐6蛋白的暘性錶達在CRA組與對照組比較有降低趨勢;而與CRC組比較則有升高趨勢,IGFBP‐6 mRNA錶達量在CRA組與對照組比較有升高趨勢;而與CRC組比較則有降低趨勢,且差異有統計學意義(P<0.05),在CRA組,IGFBP‐2、IGFBP‐6的暘性錶達與患者的年齡、性彆、腫瘤的數量及部位差異均無統計學意義(P>0.05),但是其與增生程度差異有統計學意義(P<0.05);在CRA組,IGFBP‐2與IGFBP‐6的錶達相互間呈負相關,差異有統計學意義(P<0.01)。結論 CRA在結直腸正常黏膜嚮CRC轉化過程中的中間環節,而在其髮生、髮展過程中,胰島素樣生長因子傢族(IGFs)與IGFS‐R軸髮揮著重要且不可替代的作用,所以IGFBP‐2、IGFBP‐6有可能作為CRA診斷及預後的早期預測指標。
목적:연구이도소양생장인자결합단백(IGFBP)‐2급 IGFBP‐6재결직장선류(CRA)중적표체급림상의의。방법수집승덕의학원부속의원2012년7월지2013년3월수술치료후경병리증실위CRA 50례(CRA조)、결직장암(CRC )조직표본50례(CRC조),결직장정상점막20례(대조조)。채용면역조직화학법급RT‐PCR방법검측IGFBP‐2급IGFBP‐6적단백급mRNA적표체정황,결합림상병리자료진행통계학분석。결과 IGFBP‐2단백적양성표체급mRNA적표체량재CRA조여대조조비교유승고추세;이여CRC조비교칙유강저추세,차차이유통계학의의(P<0.05),이IGFBP‐6단백적양성표체재CRA조여대조조비교유강저추세;이여CRC조비교칙유승고추세,IGFBP‐6 mRNA표체량재CRA조여대조조비교유승고추세;이여CRC조비교칙유강저추세,차차이유통계학의의(P<0.05),재CRA조,IGFBP‐2、IGFBP‐6적양성표체여환자적년령、성별、종류적수량급부위차이균무통계학의의(P>0.05),단시기여증생정도차이유통계학의의(P<0.05);재CRA조,IGFBP‐2여IGFBP‐6적표체상호간정부상관,차이유통계학의의(P<0.01)。결론 CRA재결직장정상점막향CRC전화과정중적중간배절,이재기발생、발전과정중,이도소양생장인자가족(IGFs)여IGFS‐R축발휘착중요차불가체대적작용,소이IGFBP‐2、IGFBP‐6유가능작위CRA진단급예후적조기예측지표。
Objective To study the insulin‐like growth factor binding protein (IGFBP)‐2 and IGFBP‐6 expression and clini‐cal significance in colorectal adenomas .Methods A collection of Chengde Medical College Hospital from July 2012 to March 2013 after surgical treatment of colorectal cancer confirmed by pathology (colorectal cancer ,CRC) tissue samples of 50 patients ,colorec‐tal adenomas (colorectal adenoma ,CRA) 50 cases ,20 cases of colorectal normal mucosa .Immunohistochemistry and RT‐PCR were used to detect the expression of IGFBP‐2 and IGFBP‐6 protein and mRNA ,combined with clinical and pathological data were statis‐tically analyzed .Results IGFBP‐2 protein positive expression and the amount of mRNA expression in the CRA group compared with normal colorectal mucosa had a rising trend;While compared with CRC group had a tendency to reduce ,and the differences are obvious statistical significance (P<0 .05) ,and IGFBP‐6 protein positive expression in the CRA group compared with normal color‐ectal mucosa had a lower trend;While compared with CRC group amount IGFBP‐6 mRNA expression in the CRA group compared with normal colorectal mucosa had a rising trend;While compared with CRC group had a tendency to reduce ,and the differences were obvious statistical significance (P<0 .05) .In the CRA group ,IGFBP‐2 ,IGFBP‐6 positive expression and the patient′s age , sex ,tumor and the number of parts were no significant statistical difference (P>0 .05) ,but with the degree of hyperplasia had sig‐nificant statistical difference(P<0 .05);In the CRA group ,IGFBP‐2 and IGFBP‐6 expression were negatively related to each other , and the difference was statistically significant (P<0 .01) .Conclusion Colorectal adenomas in normal colorectal mucosa of colorec‐tal cancer to the middle part of the transformation process ,and in its occurrence and development process ,insulin‐like growth factor family (IGFs) and IGFS‐R axis plays an important and irreplaceable role ,so IGFBP‐2 ,IGFBP‐6 may be used as diagnostic colorectal adenomas and early predictors of prognosis ,clinical studies on colorectal adenomas is important .