CAJ | 학술논문

目的：探讨IL－2和CD4＋CD25＋Foxp3＋调节性T细胞( Treg)在现症麻风病人外周血的变化及两者间的相关性。方法用流式细胞微球芯片捕获技术( CBA)检测30例现症麻风病人及25例正常对照者血清IL－2的浓度；用流式细胞仪检测51例麻风病人及56例正常对照者外周血CD4＋CD25＋Foxp3＋调节性T细胞(Treg)的水平。结果现症麻风病人血清中的IL－2(771.83±348.03)pg/ml高于对照组(45.03±29.05) pg/ml，外周血Treg细胞(17.626±8.1977)％高于正常对照组(9.998±1.7062)％；现症麻风病人血清IL－2浓度与外周血Treg细胞水平呈负相关线性关系。结论 IL－2和Treg细胞的调控失衡可能与麻风病人机体免疫功能异常有关。
목적：탐토IL－2화CD4＋CD25＋Foxp3＋조절성T세포( Treg)재현증마풍병인외주혈적변화급량자간적상관성。방법용류식세포미구심편포획기술( CBA)검측30례현증마풍병인급25례정상대조자혈청IL－2적농도；용류식세포의검측51례마풍병인급56례정상대조자외주혈CD4＋CD25＋Foxp3＋조절성T세포(Treg)적수평。결과현증마풍병인혈청중적IL－2(771.83±348.03)pg/ml고우대조조(45.03±29.05) pg/ml，외주혈Treg세포(17.626±8.1977)％고우정상대조조(9.998±1.7062)％；현증마풍병인혈청IL－2농도여외주혈Treg세포수평정부상관선성관계。결론 IL－2화Treg세포적조공실형가능여마풍병인궤체면역공능이상유관。
Objective To investigate the correlation between interleukin-2 and regulatory T cells ( Treg) in pa-tients with leprosy. Methods The concentration of interleukin-2 of serum of 30 patients with leprosy and 25 normal control was detected by the cytometric bead array test, and the levels of regulation T cells of 51 patients with leprosy and 56 normal control were detected by flow cytometry test. Results The concentration of serum IL-2 in patients with leprosy (771.83±348.03 pg/ml) was higher than that of normal control (45.03±29.05 pg/ml). The percentage of regulatory T cells in patients with leprosy (17.626±8.1977%) was higher than that of normal control (9.998±1. 7062%) . The expression of IL-2 and Treg cells is the linear negative correlation. Conclusion The imbalance be-tween IL-2 and Treg cells may lead to immune abnormal in patientswithleprosy.