中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2015年
17期
1355-1357
,共3页
同型半胱氨酸%高同型半胱氨酸血症%钴胺素%内皮细胞功能紊乱%儿童
同型半胱氨痠%高同型半胱氨痠血癥%鈷胺素%內皮細胞功能紊亂%兒童
동형반광안산%고동형반광안산혈증%고알소%내피세포공능문란%인동
Homocysteine%Hyperhomocysteinemia%Cobalamin%Endothelial dysfunction%Child
同型半胱氨酸(Hcy)已经证实是心血管疾病的独立危险因子,在各种病因导致的慢性肾脏病、不典型溶血尿毒综合征、甲基丙二酸尿症伴肾损伤的病例中,高同型半胱氨酸血症(HHcy)也是其突出的临床表现之一,而目前肾脏病学界对其导致的肾损伤认识尚不足.现对Hcy的合成、代谢,HHcy病因及导致心、肾损伤的发病机制,临床治疗现状等作一综述,以引起临床医师尤其是儿肾科医师的关注,提高临床综合诊治水平,改善心、肾病患儿的预后.
同型半胱氨痠(Hcy)已經證實是心血管疾病的獨立危險因子,在各種病因導緻的慢性腎髒病、不典型溶血尿毒綜閤徵、甲基丙二痠尿癥伴腎損傷的病例中,高同型半胱氨痠血癥(HHcy)也是其突齣的臨床錶現之一,而目前腎髒病學界對其導緻的腎損傷認識尚不足.現對Hcy的閤成、代謝,HHcy病因及導緻心、腎損傷的髮病機製,臨床治療現狀等作一綜述,以引起臨床醫師尤其是兒腎科醫師的關註,提高臨床綜閤診治水平,改善心、腎病患兒的預後.
동형반광안산(Hcy)이경증실시심혈관질병적독립위험인자,재각충병인도치적만성신장병、불전형용혈뇨독종합정、갑기병이산뇨증반신손상적병례중,고동형반광안산혈증(HHcy)야시기돌출적림상표현지일,이목전신장병학계대기도치적신손상인식상불족.현대Hcy적합성、대사,HHcy병인급도치심、신손상적발병궤제,림상치료현상등작일종술,이인기림상의사우기시인신과의사적관주,제고림상종합진치수평,개선심、신병환인적예후.
Homocysteine has been confirmed as the independent factor for cardiovascular disease.Hyperhomocysteinemia remains the prominent manifestation in the cases of chronic kidney disease, atypical hemolytic anemia,methylmalonic aciduria combined with kidney injuries.As the recognition of the kidney injuries caused by homocysteine remains obscure, this review tries to show the synthesis, metabolism of homocysteine and the possible mechanism of homocysteine-induced heart and kidney injuries.Besides, summarize the current treatment of lowering-hyperhomocysteinemia in order to arouse the pediatricians' attention of homocysteine which has endothelial cell toxicity and causes the wide lesions in great, middle and small vessels, and thus improve the outcomes of the patients.