CAJ | 학술논문

目的：评价类风湿因子（RF）、C反应蛋白（CRP）、红细胞沉降率（ESR）诊断类风湿关节炎（RA）的价值。方法随机选取RA患者74例（RA组），与RA症状相似的非RA患者90例（对照组），检测两组患者的RF、CRP、ESR水平并进行组间比较，用受试者工作特征曲线（ROC）评价这3项指标用于RA诊断的效能。结果 RA 组 RF、CRP、ESR分别为（271．4±560．9） IU／mL、（28．7±35．6）mg／L、（60．9±40．1）mm／h ，均分别高于对照组的（56．8±189．3）IU／mL、（15．4±24．7）mg／L、（45．1±33．1）mm／h ；ROC曲线RF、CRP、ESR单独检测以及3项联合检测用于诊断的ROC曲线下面积（AUC）分别为0．784、0．666、0．615、0．757，均有统计学意义（P＜0．05）。结论 RF、CRP、ESR在RA诊断中均有一定价值，以RF的诊断效能最高。
목적：평개류풍습인자（RF）、C반응단백（CRP）、홍세포침강솔（ESR）진단류풍습관절염（RA）적개치。방법수궤선취RA환자74례（RA조），여RA증상상사적비RA환자90례（대조조），검측량조환자적RF、CRP、ESR수평병진행조간비교，용수시자공작특정곡선（ROC）평개저3항지표용우RA진단적효능。결과 RA 조 RF、CRP、ESR분별위（271．4±560．9） IU／mL、（28．7±35．6）mg／L、（60．9±40．1）mm／h ，균분별고우대조조적（56．8±189．3）IU／mL、（15．4±24．7）mg／L、（45．1±33．1）mm／h ；ROC곡선RF、CRP、ESR단독검측이급3항연합검측용우진단적ROC곡선하면적（AUC）분별위0．784、0．666、0．615、0．757，균유통계학의의（P＜0．05）。결론 RF、CRP、ESR재RA진단중균유일정개치，이RF적진단효능최고。
Objective To investigate the role of rheumatoid factor(RF) ,C‐reactive protein(CRP) ,erythrocyte sedimentation rate (ESR) in the diagnosis of rheumatoid arthritis(RA) .Methods 74 RA patients and 90 patients with symptoms similar to RA were recruited in the study randomly .Blood samples were detected for the levels of RF ,CRP ,ESR .The results were compared between two groups .Receiver operating characteristic curve(ROC) was used to access the diagnostic efficiency .Results The levels of RF , CRP ,ESR of RA group were (271 .4 ± 560 .9)IU/mL ,(28 .7 ± 35 .6)mg/L ,(60 .9 ± 40 .1)mm/h ,respectively ,and were higher than those of control group which were (56 .8 ± 189 .3)IU/mL ,(15 .4 ± 24 .7)mg/L ,(45 .1 ± 33 .1)mm/h respectively .ROC analysis re‐vealed that the AUC of RF ,CRP ,ESR and combined detection of the 3 factors were 0 .784 ,0 .666 ,0 .615 ,0 .757 ,respectively with statistical significance(P<0 .05) .Conclusion RF ,CRP ,ESR are useful in the diagnosis of RA ,and RF has the highest diagnostic ef f iciency .