CAJ | 학술논문

目的：评价脑脊液乳酸脱氢酶（LDH ）在中枢神经系统疾病早期诊断和鉴别诊断中应用价值。方法用速率法检测对照组和疾病组（其中包括急性白血病患者，淋巴瘤患者，脑肿瘤患者，脑膜炎患者）脑脊液中的LDH。结果急性白血病患者中的中枢神经系统白血病（CNSL）组脑脊液中 LDH水平为（28．68±9．29）U／L，高于无CNSL组，两者比较差异具有统计学意义（P＜0．05）；淋巴瘤患者中脑转移组脑脊液LDH水平为（125．20±115．24）U／L，高于无脑转移组，两者比较差异具有统计学意义（P＜0．05）；脑肿瘤患者中脑膜癌病组脑脊液中LDH水平为（77．37±128．15）U／L，高于原发性脑肿瘤组，两者比较差异具有统计学意义（P＜0．05）；脑膜炎患者中化脓性脑膜炎组脑脊液中LDH水平为（54．48±84．60）U／L，高于病毒性脑膜炎组，两者比较差异具有统计学意义（P＜0．05）。结核性脑膜炎组患者脑脊液中LDH水平为（43．54±32．05）U／L，高于病毒性脑膜炎组，两者比较差异具有统计学意义（P＜0．05）。结论脑脊液中LDH检测对CNSL、淋巴瘤脑转移及脑膜癌的早期诊断、脑膜炎的鉴别诊断具有重要临床意义。
목적：평개뇌척액유산탈경매（LDH ）재중추신경계통질병조기진단화감별진단중응용개치。방법용속솔법검측대조조화질병조（기중포괄급성백혈병환자，림파류환자，뇌종류환자，뇌막염환자）뇌척액중적LDH。결과급성백혈병환자중적중추신경계통백혈병（CNSL）조뇌척액중 LDH수평위（28．68±9．29）U／L，고우무CNSL조，량자비교차이구유통계학의의（P＜0．05）；림파류환자중뇌전이조뇌척액LDH수평위（125．20±115．24）U／L，고우무뇌전이조，량자비교차이구유통계학의의（P＜0．05）；뇌종류환자중뇌막암병조뇌척액중LDH수평위（77．37±128．15）U／L，고우원발성뇌종류조，량자비교차이구유통계학의의（P＜0．05）；뇌막염환자중화농성뇌막염조뇌척액중LDH수평위（54．48±84．60）U／L，고우병독성뇌막염조，량자비교차이구유통계학의의（P＜0．05）。결핵성뇌막염조환자뇌척액중LDH수평위（43．54±32．05）U／L，고우병독성뇌막염조，량자비교차이구유통계학의의（P＜0．05）。결론뇌척액중LDH검측대CNSL、림파류뇌전이급뇌막암적조기진단、뇌막염적감별진단구유중요림상의의。
Objective To evaluate the levels of LDH in cerebrospinal fluid in patients with different types of central nervous sys‐tem diseases .Methods Cerebrospinal fluid LDH were detected by rate assay in control group and disease group(including patients with acute leukemia ,lymphoma ,brain neoplasms and meningitis) .Results In ptients with acute leukemia ,the cerebrospinal fluid LDH level of central nervous system leukemia(CNSL) group was (28 .68 ± 9 .29)U/L ,which was higher than that of non CNSL group ,and the difference were significance(P<0 .05) .In lymphoma patients ,cerebrospinal fluid LDH level of brain metastasis pa‐tients was (125 .20 ± 115 .24)U/L ,which was higher than that of lymphoma patients without brain metastasis ,the difference was significant(P<0 .05) .In patients with brain neoplasms ,cerebrospinal fluid LDH level of meningeal carcinomatosis group was (77 . 37 ± 128 .15)U/L ,which was higher than that of primary brain neoplasms group ,the difference was significant(P<0 .05) .In pa‐tients with meningitis ,cerebrospinal fluid LDH level of tuberculous meningitis group and purulent meningitis group patients were (54 .48 ± 84 .60U/L) and (43 .54 ± 32 .05)U/L respectively ,which were higher than those of viral meningitis group patients ,and the differences were significant (P<0 .05) .Conclusion LDH in cerebrospinal fluid can be used in early diagnosis of CNSL ,brain metastsisly of mphoma ,meningeal carcinomatosis and differential diagnosis of meningitis .