中国医疗设备
中國醫療設備
중국의료설비
China Medical Devices
2015年
10期
51-54
,共4页
头颈部鳞状细胞癌%正电子发射断层/计算机断层扫描%microRNA%肿瘤标志物
頭頸部鱗狀細胞癌%正電子髮射斷層/計算機斷層掃描%microRNA%腫瘤標誌物
두경부린상세포암%정전자발사단층/계산궤단층소묘%microRNA%종류표지물
head and neck squamous cell cancer%positron emission tomography/computed tomography%micro-RNA%tumor markers
目的：探讨一种新型microRNA试剂盒联合正电子发射断层/计算机断层扫描（PET/CT）对头颈部鳞状细胞癌术后转移的诊断价值。方法选取40例行全身PET/CT检查的头颈部鳞状细胞癌术后病例，提取外周血标本，应用包含4种microRNAs的试剂盒诊断肿瘤术后转移，并与病理诊断结果进行比较，分析两种检查方法及联合检查的敏感性、特异性及准确性。结果40例病例中，28例经病理诊断为头颈部鳞状细胞癌转移。microRNA试剂盒诊断头颈部鳞状细胞癌术后转移的灵敏度为96.43%，特异度为83.33%，准确度为92.50%；PET/CT诊断的灵敏度为89.29%，特异度为91.67%，准确度为90.00%；两者联合诊断的灵敏度为100%，特异度为83.33%，准确度为95.00%。结论 PET/CT诊断头颈部鳞状细胞癌术后转移的特异性较microRNA试剂盒高，而敏感性不足，microRNA试剂盒对PET/CT诊断具有补充作用，两者联合应用是诊断头颈部鳞状细胞癌术后转移的更为理想的方法。
目的：探討一種新型microRNA試劑盒聯閤正電子髮射斷層/計算機斷層掃描（PET/CT）對頭頸部鱗狀細胞癌術後轉移的診斷價值。方法選取40例行全身PET/CT檢查的頭頸部鱗狀細胞癌術後病例，提取外週血標本，應用包含4種microRNAs的試劑盒診斷腫瘤術後轉移，併與病理診斷結果進行比較，分析兩種檢查方法及聯閤檢查的敏感性、特異性及準確性。結果40例病例中，28例經病理診斷為頭頸部鱗狀細胞癌轉移。microRNA試劑盒診斷頭頸部鱗狀細胞癌術後轉移的靈敏度為96.43%，特異度為83.33%，準確度為92.50%；PET/CT診斷的靈敏度為89.29%，特異度為91.67%，準確度為90.00%；兩者聯閤診斷的靈敏度為100%，特異度為83.33%，準確度為95.00%。結論 PET/CT診斷頭頸部鱗狀細胞癌術後轉移的特異性較microRNA試劑盒高，而敏感性不足，microRNA試劑盒對PET/CT診斷具有補充作用，兩者聯閤應用是診斷頭頸部鱗狀細胞癌術後轉移的更為理想的方法。
목적：탐토일충신형microRNA시제합연합정전자발사단층/계산궤단층소묘（PET/CT）대두경부린상세포암술후전이적진단개치。방법선취40례행전신PET/CT검사적두경부린상세포암술후병례，제취외주혈표본，응용포함4충microRNAs적시제합진단종류술후전이，병여병리진단결과진행비교，분석량충검사방법급연합검사적민감성、특이성급준학성。결과40례병례중，28례경병리진단위두경부린상세포암전이。microRNA시제합진단두경부린상세포암술후전이적령민도위96.43%，특이도위83.33%，준학도위92.50%；PET/CT진단적령민도위89.29%，특이도위91.67%，준학도위90.00%；량자연합진단적령민도위100%，특이도위83.33%，준학도위95.00%。결론 PET/CT진단두경부린상세포암술후전이적특이성교microRNA시제합고，이민감성불족，microRNA시제합대PET/CT진단구유보충작용，량자연합응용시진단두경부린상세포암술후전이적경위이상적방법。
Objective To discuss the application value of positron emission tomography/computed tomography (PET/CT) and micro-RNA in diagnosis of post-operative metastasis of head and neck squamous cell cancers.Methods Altogether 40 patients with surgical history of head and neck cancer simultaneously underwent the examination of PET/CT in combination with a micro-RNA kit that was comprised four micro-RNAs. The results were compared with the ifnal diagnosis so as to analyze the sensitivity, speciifcity and accuracy of these two diagnosis methods.Results Of those 40 cases, 28 were found with metastases of head and neck squamous cell carcinoma as was diagnosed pathologically. The sensitivity, speciifcity and accuracy of the micro-RNA kit for diagnosis of metastasis were 96.43%, 83.33% and 92.50%. While, those of PET/CT were 89.29%, 91.67% and 90.00%, respectively. Promisingly, those by the detection of PET/CT combined with the micro-RNA kit were 100%, 83.33%and 95.00%.Conclusion PET/CT showed higher specificity and lower sensitivity in assessment of postoperative metastasis of head and neck cancers than those by the micro-RNA kit. The micro-RNA kit detection may be used as a supplementary tool to PET/CT examination. Combined use of the two examinations was an ideal strategy for detecting the metastases of head and neck cancers.
