CAJ | 학술논문

目的：分析急性冠状动脉综合征（ACS）及其不同亚组的血浆非对称二甲基精氨酸（ADMA）浓度，并分析ADMA与ACS传统危险因素的关系。方法根据临床诊断、心电图检查及冠状动脉造影结果，将 ACS组患者101例分为不稳定型心绞痛（UA）组（70例）和急性心肌梗死（AMI）组（31例），其中AMI组包括非ST段抬高型心肌梗死（NSTEMI）组（19例）和ST段抬高型心肌梗死（STEMI）组（12例）；对照组（40例）为同期冠状动脉造影显示冠状动脉正常的患者。通过酶联免疫吸附测定（ELISA）检测血浆标本ADMA水平，同时应用全自动生化分析仪测血脂[总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL‐C）、低密度脂蛋白胆固醇（LDL‐C）]、C反应蛋白（CRP）及肌钙蛋白水平。结果与对照组比较，ACS组血浆ADMA浓度增高，差异有统计学意义（P＜0．05）。AMI组、UA组血浆ADMA浓度均高于对照组，差异均有统计学意义（P＜0．05）。AMI组血浆AD‐MA浓度高于UA组，差异有统计学意义（P＜0．05）。血浆ADMA水平与 HDL‐C呈负相关（r＝－0．222，P＜0．05），与LDL‐C呈正相关（r＝0．357，P＜0．05），与CRP呈正相关（r＝0．619，P＜0．05）。结论血浆ADMA水平与ACS的发生及其部分危险因素有一定相关性。
목적：분석급성관상동맥종합정（ACS）급기불동아조적혈장비대칭이갑기정안산（ADMA）농도，병분석ADMA여ACS전통위험인소적관계。방법근거림상진단、심전도검사급관상동맥조영결과，장 ACS조환자101례분위불은정형심교통（UA）조（70례）화급성심기경사（AMI）조（31례），기중AMI조포괄비ST단태고형심기경사（NSTEMI）조（19례）화ST단태고형심기경사（STEMI）조（12례）；대조조（40례）위동기관상동맥조영현시관상동맥정상적환자。통과매련면역흡부측정（ELISA）검측혈장표본ADMA수평，동시응용전자동생화분석의측혈지[총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL‐C）、저밀도지단백담고순（LDL‐C）]、C반응단백（CRP）급기개단백수평。결과여대조조비교，ACS조혈장ADMA농도증고，차이유통계학의의（P＜0．05）。AMI조、UA조혈장ADMA농도균고우대조조，차이균유통계학의의（P＜0．05）。AMI조혈장AD‐MA농도고우UA조，차이유통계학의의（P＜0．05）。혈장ADMA수평여 HDL‐C정부상관（r＝－0．222，P＜0．05），여LDL‐C정정상관（r＝0．357，P＜0．05），여CRP정정상관（r＝0．619，P＜0．05）。결론혈장ADMA수평여ACS적발생급기부분위험인소유일정상관성。
Objective To study the asymmetric dimethylarginine(ADMA) concentrations in plasma of acute coronary syndrome (ACS) and its various subgroups ,and analyze the relationship between ADMA and traditional risk factors of ACS .Methods 101 ACS patients were enrolled in the study ,which were divided into several subgroups according to clinical diagnosis ,ECG and coro‐nary angiography .ACS group were divided into unstable angina(UA) group(n=70) and acute myocardial infarction(AMI) group (n=31) ,then AMI group was divided into non‐ST segment elevation myocardial infarction(NSTEMI) group(n=19) and ST seg‐ment elevation myocardial infarction (STEMI) group(n=12) .The control group(n= 40) were recruited in the study during the same period ,who showed normal coronary arteries in coronary angiography .All the patients received coronary attery angiography . The plasma ADMA concentration was measured by using enzyme‐linked immunosorbent assay (ELISA) ,and serum contents of lip‐id(TC ,TG ,HDL‐C ,LDL‐C) ,C‐reactive protein(CRP) ,troponin were detected by automatic biochemic analysis apparatus .Results Compared with the control group ,plasma ADMA concentration of ACS group increased ,the difference was statistically significant (P<0 .05) .The concentrations of ADMA in AMI group and UA group were higher than those in control group ,and the difference was statistically significant(P< 0 .05) .The concentrations of ADMA in AMI group were significantly higher than those in UA group(P<0 .05) .Plasma ADMA negatively correlated with HDL‐C concentrations(r= -0 .222 ,P<0 .05) ,positively correlated with LDL‐C concentration(r=0 .357 ,P<0 .05) ,and positively correlated with CRP(r=0 .619 ,P<0 .05) .Conclusion The occur‐rence of ACS and some of its related risk factors are correlated with plasma ADMA concentration .