CAJ | 학술논문

目的：探讨原发性醛固酮增多症（PA ）男性患者的糖、脂代谢特征。方法选取125例经血浆醛固酮‐肾素活性比值（ARR）联合血浆醛固酮水平检测筛查出的PA男性患者（PA组），同时选取血压水平和高血压病程与PA组相似的本院门诊及住院原发性高血压（EH）男性患者127例（EH组）。收集各组的临床资料和生化指标检测结果，分析男性 PA患者的糖、脂代谢特点。结果 PA组血钾水平比EH组低，PA组三酰甘油水平高于EH组，PA组 HDL‐C水平比EH组低，PA组口服葡萄糖耐量试验（OGTT）2 h血糖水平高于EH组，PA组腰围大于EH组，差异均有统计学意义（P＜0．05）。结论与EH患者相比，PA男性患者糖、脂代谢异常加重，主要表现为腹型肥胖及糖耐量异常。
목적：탐토원발성철고동증다증（PA ）남성환자적당、지대사특정。방법선취125례경혈장철고동‐신소활성비치（ARR）연합혈장철고동수평검측사사출적PA남성환자（PA조），동시선취혈압수평화고혈압병정여PA조상사적본원문진급주원원발성고혈압（EH）남성환자127례（EH조）。수집각조적림상자료화생화지표검측결과，분석남성 PA환자적당、지대사특점。결과 PA조혈갑수평비EH조저，PA조삼선감유수평고우EH조，PA조 HDL‐C수평비EH조저，PA조구복포도당내량시험（OGTT）2 h혈당수평고우EH조，PA조요위대우EH조，차이균유통계학의의（P＜0．05）。결론여EH환자상비，PA남성환자당、지대사이상가중，주요표현위복형비반급당내량이상。
Objective To investigate the characteristics of glucose and lipid metabolism in the male primary aldosteronism(PA) patients .Methods 125 male PA patients screened out by using plasma aldosterone/renin ratio(ARR) plasma aldosterone concen‐tration measurement were enrolled in the study(PA group) ,at the same time 127 male patients with essential hypertension(EH) were also recruited as EH group ,who had similar blood pressure levels and hypertension course .Clinical data and biochemical indi‐cators of each group were collected and the characteristics of glucose and lipid metabolism in the male PA patients were analyzed . Results Serum potassium level of PA group was lower than EH group(P<0 .05) .Compared with EH group ,there were significant increase of triglycerides concentration in PA group(P<0 .05) ,and significant decrease of HDL‐C concentration in PA group(P<0 .05) .Oral glucose tolerance test(OGTT) 2 h glucose level and waist in PA group were higher or larger than that in EH group (P<0 .05) .Conclusion Compared with EH patients ,glucose and lipid metabolism disorder are more severe in male PA patients , the symptoms are mainly abdominal obesity and impaired glucose tolerance .