国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
International Journal of Laboratory Medicine
2015年
20期
2967-2968
,共2页
高血压肾病%同型半胱氨酸%中性粒细胞明胶酶相关脂质运载蛋白%尿蛋白排泄率
高血壓腎病%同型半胱氨痠%中性粒細胞明膠酶相關脂質運載蛋白%尿蛋白排洩率
고혈압신병%동형반광안산%중성립세포명효매상관지질운재단백%뇨단백배설솔
hypertensive nephropathy%homocysteine%neutrophil gelatinase-associated lipocalin%urinary albumin excretion rate
目的：分析血清同型半胱氨酸（Hcy）和尿液中性粒细胞明胶酶相关脂质运载蛋白（NGAL ）对高血压肾病的诊断价值，并探讨尿清蛋白排泄率（UAER）与 Hcy、NGAL水平的关系。方法选取2012年1月至2014年1月黄石市中心医院肾内科和心血管内科门诊高血压患者103例，分为大量蛋白尿组36例，微量蛋白尿组35例，尿蛋白正常组32例。另外，在体检中心随机选择33例体检健康者作为对照组。检测上述纳入研究者的血清 Hcy、NGAL水平及 UAER。结果大量蛋白尿组和微量蛋白尿组血清Hcy和NGAL水平均高于尿蛋白正常组和对照组，差异均有统计学意义（P＜0．05）。大量蛋白尿组和微量蛋白尿组血清Hcy和NGAL水平比较，差异有统计学意义（P＜0．05）。尿蛋白正常组和对照组血清 Hcy和NGAL水平比较，差异无统计学意义（P＞0．05）。高血压肾病患者UAER与血清Hcy、NGAL水平均呈正相关（r分别为0．792、0．658，P＜0．05）。结论监测高血压肾病患者血清 Hcy和尿液NGAL水平有助于了解其病情变化。
目的：分析血清同型半胱氨痠（Hcy）和尿液中性粒細胞明膠酶相關脂質運載蛋白（NGAL ）對高血壓腎病的診斷價值，併探討尿清蛋白排洩率（UAER）與 Hcy、NGAL水平的關繫。方法選取2012年1月至2014年1月黃石市中心醫院腎內科和心血管內科門診高血壓患者103例，分為大量蛋白尿組36例，微量蛋白尿組35例，尿蛋白正常組32例。另外，在體檢中心隨機選擇33例體檢健康者作為對照組。檢測上述納入研究者的血清 Hcy、NGAL水平及 UAER。結果大量蛋白尿組和微量蛋白尿組血清Hcy和NGAL水平均高于尿蛋白正常組和對照組，差異均有統計學意義（P＜0．05）。大量蛋白尿組和微量蛋白尿組血清Hcy和NGAL水平比較，差異有統計學意義（P＜0．05）。尿蛋白正常組和對照組血清 Hcy和NGAL水平比較，差異無統計學意義（P＞0．05）。高血壓腎病患者UAER與血清Hcy、NGAL水平均呈正相關（r分彆為0．792、0．658，P＜0．05）。結論鑑測高血壓腎病患者血清 Hcy和尿液NGAL水平有助于瞭解其病情變化。
목적：분석혈청동형반광안산（Hcy）화뇨액중성립세포명효매상관지질운재단백（NGAL ）대고혈압신병적진단개치，병탐토뇨청단백배설솔（UAER）여 Hcy、NGAL수평적관계。방법선취2012년1월지2014년1월황석시중심의원신내과화심혈관내과문진고혈압환자103례，분위대량단백뇨조36례，미량단백뇨조35례，뇨단백정상조32례。령외，재체검중심수궤선택33례체검건강자작위대조조。검측상술납입연구자적혈청 Hcy、NGAL수평급 UAER。결과대량단백뇨조화미량단백뇨조혈청Hcy화NGAL수평균고우뇨단백정상조화대조조，차이균유통계학의의（P＜0．05）。대량단백뇨조화미량단백뇨조혈청Hcy화NGAL수평비교，차이유통계학의의（P＜0．05）。뇨단백정상조화대조조혈청 Hcy화NGAL수평비교，차이무통계학의의（P＞0．05）。고혈압신병환자UAER여혈청Hcy、NGAL수평균정정상관（r분별위0．792、0．658，P＜0．05）。결론감측고혈압신병환자혈청 Hcy화뇨액NGAL수평유조우료해기병정변화。
Objective To analyse the clinical significance of serum homocysteine(Hcy) and neutrophil gelatinase‐associated li‐pocalin(NGAL) in patients with hypertensive nephropathy ,and explore the relationship between serum homocysteine ,NGAL con‐centration and Urinary albumin excretion rate(UAER) .Methods 103 patients with hypertension treated in renal and cardiovascular department of Huangshi Central Hospital from January 2012 to June 2014 were enrolled in the study and were divided into 3 groups :macroalbuminuria group (36 cases) ,microalbuminuria group (35 cases) and negative albuminuria group (32 cases) .In addi‐tion to that ,33 healthy people were recruited as control group .Serum homocysteine ,NGAL concentration and UAER were meas‐ured for the peple enrolled in the study .Results Serum homocysteine and NGAL concentration of macroalbuminuria group and mi‐croalbuminuria group were much higher than negative albuminuria group and control group(P<0 .05) .Serum homocysteine and NGAL concentrations compared between macroalbuminuria group and microalbuminuria group were significantly different (P<0 .05) .Serum homocysteine and NGAL concentrations of negative albuminuria group and control group were not significantly dif‐ferent(P>0 .05) .UAER was positively correlated with serum homocysteine and NGAL concentration(r=0 .792 ,0 .658 ,P<0 .05) . Conclusion The detection of serum homocysteine and NGAL are helpful in understanding the changes of disease in patients with hypertensive nephropathy .
