CAJ | 학술논문

目的：探讨老年类风湿性关节炎（RA）患者抗核抗体（ANA）、抗环瓜氨酸肽（CCP）抗体（抗‐CCP）表达与抑郁的相关性。方法检测58例老年RA患者（RA组）、50例非RA患者（非RA组）及50例健康体检者（对照组）的ANA、抗‐CCP ，采用抑郁自评量表（SDS）调查RA患者抑郁发生情况，并分析其与ANA、抗‐CCP表达的相关性。结果 RA组抗‐CCP的阳性率明显高于非RA组和对照组（P＜0．05），而ANA阳性率RA组与非RA组比较差异无统计学意义（P＞0．05）；活动期患者的ANA、抗‐CCP阳性率高于稳定期（P＜0．05）；合并抑郁的患者ANA、抗‐CCP的阳性率明显高于无抑郁者（P＜0．05）；多元线性回归显示， ANA、抗‐CCP的阳性均是老年RA患者抑郁的独立影响因素（P＜0．05）。结论老年 RA患者 ANA、抗‐CCP表达明显升高且与病情活动性及抑郁情绪相关。
목적：탐토노년류풍습성관절염（RA）환자항핵항체（ANA）、항배과안산태（CCP）항체（항‐CCP）표체여억욱적상관성。방법검측58례노년RA환자（RA조）、50례비RA환자（비RA조）급50례건강체검자（대조조）적ANA、항‐CCP ，채용억욱자평량표（SDS）조사RA환자억욱발생정황，병분석기여ANA、항‐CCP표체적상관성。결과 RA조항‐CCP적양성솔명현고우비RA조화대조조（P＜0．05），이ANA양성솔RA조여비RA조비교차이무통계학의의（P＞0．05）；활동기환자적ANA、항‐CCP양성솔고우은정기（P＜0．05）；합병억욱적환자ANA、항‐CCP적양성솔명현고우무억욱자（P＜0．05）；다원선성회귀현시， ANA、항‐CCP적양성균시노년RA환자억욱적독립영향인소（P＜0．05）。결론노년 RA환자 ANA、항‐CCP표체명현승고차여병정활동성급억욱정서상관。
Objective To investigate the expression of antinuclear antibodies(ANA) ,anti‐cyclic citrullinated peptide antibody (anti‐CCP) in elderly patients with rheumatoid arthritis(RA) ,and analyze its relation with depression .Methods ANA ,anti‐CCP were detected in 58 elderly RA patients ,50 non‐RA and 50 healthy people .Self‐rating Depression Scale(SDS) was used to assess the incidence of depression .Results The positive rate of anti‐CCP in RA group was significantly higher than that in control group and non‐RA group(P<0 .05) ,while there was no significantly difference in positive rate of ANA compared between RA group and non‐RA group(P>0 .05) .The positive rates of anti‐CCP and ANA in active stage were significantly higher than those in stable stage(P<0 .05) .The positive rates of anti‐CCP and ANA in RA complicated with depression were significantly higher than those in RA without depression(P<0 .05) .Multiple linear regression analysis showed that positive rates of anti‐CCP and ANA were all in‐dependent influence factors of depression in elderly RA patients(P<0 .05) .Conclusion Anti‐CCP and ANA in elderly RA patients over express ,and the positive rates are positively related with disease activity and depression .