CAJ | 학술논문

采用气相色谱－质谱联用（Gas chromatography－mass spectrometry ，GC－MS ）技术对养心生脉颗粒的挥发性成分进行分析，为该制剂的化学成分研究及其质量控制提供理论基础。采用挥发油测定法，提取养心生脉颗粒中的挥发油成分，以毛细管柱进行GC分析，用MS对其化学成分进行鉴定，用面积归一化法测定其相对含量。共分离出31个化学成分，鉴定出其中的25种成分，相对含量较高的成分有棕榈酸（49.25％）、亚油酸（20.94％）、反式－9－十八碳烯酸（3.58％）和硬脂酸（3.28％）。养心生脉颗粒中挥发油成分主要为烷烃、酯类、脂肪酸等。
채용기상색보－질보련용（Gas chromatography－mass spectrometry ，GC－MS ）기술대양심생맥과립적휘발성성분진행분석，위해제제적화학성분연구급기질량공제제공이론기출。채용휘발유측정법，제취양심생맥과립중적휘발유성분，이모세관주진행GC분석，용MS대기화학성분진행감정，용면적귀일화법측정기상대함량。공분리출31개화학성분，감정출기중적25충성분，상대함량교고적성분유종려산（49.25％）、아유산（20.94％）、반식－9－십팔탄희산（3.58％）화경지산（3.28％）。양심생맥과립중휘발유성분주요위완경、지류、지방산등。
GC-MS (gas chromatography-mass spectrometry ) was used to analyze the volatile oil components in Yangxinshengmai Granule to provide theoretical basis for determination of its chemical constituents and quality control .The volatile oil of Yangxinshengmai Granule was ex-tracted with steam distillation method ,the chemical compositions were separated by GC capillary column chromatography and identified by mass spectrometry ,and the relative content of constituents were determined by area normalization method .31 compounds were detected and 25 com-pounds of them were identified .And the compounds with higher relative contents were Palmitic acid (49.25% ) ,Linoleic acid (20.94% ) ,9-trans-Octadecenoic acid(3.58% ) ,and Stearic acid(3.28% ) ,respectively .The main components in volatile oil of Yangxinshengmai Granule were alkanes ,esters and fatty acid ,etc .