中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
10期
2526-2528
,共3页
乳腺癌%BCCIP蛋白%免疫组织化学
乳腺癌%BCCIP蛋白%免疫組織化學
유선암%BCCIP단백%면역조직화학
Breast cancer%BCCIP protein%Immunohistochmistry
目的 探讨BCCIP在乳腺癌患者组织中的表达及临床意义.方法 采用免疫组织化学法检测23例良性乳腺肿瘤、68例乳腺癌BCCIP的表达,并分析与临床病理因素相关性.结果 BCCIP在乳腺癌及良性肿瘤组织中的表达:BCCIP在乳腺癌中的阳性表达率为47.05％(32/68),在良性肿瘤中的阳性表达率为73.91％(17/23),两组差异有统计学意义(x2=4.987,P＜0.05).BCCIP蛋白表达与发病年龄、组织学分级、淋巴结转移、人类表皮生长因子受体2(Her-2)表达有关;BCCIP在≤35岁乳腺癌中的阳性表达率为29.41％ (5/17),在＞35岁乳腺癌中的阳性表达率为56.86％ (29/51),两组差异有统计学意义(x2=3.787,P＜0.05).随着组织学分级增高,BCCIP表达降低;在有淋巴结转移者中BCCIP表达降低;Her-2阳性患者BCCIP表达降低.结论 在乳腺癌组织中BCCIP蛋白表达水平显著下降.其蛋白表达水平有助于判断乳腺恶性肿瘤的患者的预后.
目的 探討BCCIP在乳腺癌患者組織中的錶達及臨床意義.方法 採用免疫組織化學法檢測23例良性乳腺腫瘤、68例乳腺癌BCCIP的錶達,併分析與臨床病理因素相關性.結果 BCCIP在乳腺癌及良性腫瘤組織中的錶達:BCCIP在乳腺癌中的暘性錶達率為47.05％(32/68),在良性腫瘤中的暘性錶達率為73.91％(17/23),兩組差異有統計學意義(x2=4.987,P＜0.05).BCCIP蛋白錶達與髮病年齡、組織學分級、淋巴結轉移、人類錶皮生長因子受體2(Her-2)錶達有關;BCCIP在≤35歲乳腺癌中的暘性錶達率為29.41％ (5/17),在＞35歲乳腺癌中的暘性錶達率為56.86％ (29/51),兩組差異有統計學意義(x2=3.787,P＜0.05).隨著組織學分級增高,BCCIP錶達降低;在有淋巴結轉移者中BCCIP錶達降低;Her-2暘性患者BCCIP錶達降低.結論 在乳腺癌組織中BCCIP蛋白錶達水平顯著下降.其蛋白錶達水平有助于判斷乳腺噁性腫瘤的患者的預後.
목적 탐토BCCIP재유선암환자조직중적표체급림상의의.방법 채용면역조직화학법검측23례량성유선종류、68례유선암BCCIP적표체,병분석여림상병리인소상관성.결과 BCCIP재유선암급량성종류조직중적표체:BCCIP재유선암중적양성표체솔위47.05％(32/68),재량성종류중적양성표체솔위73.91％(17/23),량조차이유통계학의의(x2=4.987,P＜0.05).BCCIP단백표체여발병년령、조직학분급、림파결전이、인류표피생장인자수체2(Her-2)표체유관;BCCIP재≤35세유선암중적양성표체솔위29.41％ (5/17),재＞35세유선암중적양성표체솔위56.86％ (29/51),량조차이유통계학의의(x2=3.787,P＜0.05).수착조직학분급증고,BCCIP표체강저;재유림파결전이자중BCCIP표체강저;Her-2양성환자BCCIP표체강저.결론 재유선암조직중BCCIP단백표체수평현저하강.기단백표체수평유조우판단유선악성종류적환자적예후.
Objective To investigate the expression of BCCIP protein in breascancetissueand the clinical significance.MethodWe detected the expression level of BCCIP protein in 23 caseof benign tumotissueand 68 caseof malignanbreasby immunohistochemistry.Univariate analysewere used to make cleathe relationship of BCCIP protein expression and clinical datof patients.ResultBCCIP expression rate in breascancetissuewa47.05％ (32/68), and thain benign tumotissuewa73.91％ (17/23).The difference wastatistically significan(x2 =4.987 ,P ＜0.05).BCCIP protein expression wacorrelated to age, histological grade, lymph node metastasis, and human epidermalgrowth factoreceptor-2 (Her-2) expression.The positive rate of BCCIP expression in the group of ≤ 35 yearwalowethan thain the group of oldethan 35-yea(29.41％ vs.56.86％), and the difference wastatistically significan(x2 =3.787, P ＜ 0.05).BCCIP expression wadecreased with highehistological grade, lymph node metastasiand Her-2 positive expression.Conclusion BCCIP expression wareduced significantly in malignanbreastissues.The expression of BCCIP protein could be used aprognosifactofomalignanbreastumopatients.
